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- W2029779916 abstract "In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inhibited TPA-promoted transformation in a dose-dependent manner. Most of them achieved a 70-80% inhibition. Good correlations were observed between the inhibition of TPA-promoted transformation and that of 5-LO. These results indicate that 5-LO plays an important role in the promotion stage of the transformation of BALB 3T3 cells." @default.
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- W2029779916 date "1993-07-01" @default.
- W2029779916 modified "2023-09-24" @default.
- W2029779916 title "Antipromoting effects of 5-lipoxygenase inhibitors, 3-nitro-2,4,6-trihydroxybenzamide derivatives, on TPA-promoted transformation in BALB 3T3 cells" @default.
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- W2029779916 doi "https://doi.org/10.1016/0304-3835(93)90097-s" @default.
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