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- W2029783596 abstract "The signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) family of adaptors couples SLAM family receptors to activating intracellular signaling pathways that drive immune cell activation or differentiation. In the absence of SAP family adaptors, SLAM family receptors become inhibitory, possibly through coupling to the Src-homology-2-containing phosphatases. This switch-of-function of SLAM family receptors provides an explanation for the severe immune dysfunctions observed in humans with X-linked lymphoproliferative disease due to SAP deficiency, as well as in genetically engineered mice that lack SAP family adaptors." @default.
- W2029783596 created "2016-06-24" @default.
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- W2029783596 date "2010-08-01" @default.
- W2029783596 modified "2023-10-03" @default.
- W2029783596 title "How do SAP family deficiencies compromise immunity?" @default.
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- W2029783596 doi "https://doi.org/10.1016/j.it.2010.05.008" @default.
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