Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029786514> ?p ?o ?g. }
- W2029786514 endingPage "619" @default.
- W2029786514 startingPage "613" @default.
- W2029786514 abstract "Arachidonic acid (AA) signaling is upregulated in the caudate-putamen and frontal cortex of unilaterally 6-hydroxydopamine (6-OHDA) lesioned rats, a model for asymmetrical Parkinson disease. AA signaling can be coupled to D2-like receptor initiated AA hydrolysis from phospholipids by cytosolic phospholipase A2 (cPLA2) and subsequent metabolism by cyclooxygenase (COX)-2. In unilaterally 6-OHDA- and sham-lesioned rats, we measured brain expression of cPLA2, other PLA2 enzymes, and COX-2. Activity and protein levels of cPLA2 were significantly higher as was COX-2-protein in caudate-putamen, frontal cortex and remaining brain on the lesioned compared to intact side of the 6-OHDA lesioned rats, and compared to sham brain. Secretory sPLA2 and Ca2+-independent iPLA2 expression did not differ between sides or groups. Thus, the tonically increased ipsilateral AA signal in the lesioned rat corresponds to upregulated cPLA2 and COX-2 expression within the AA metabolic cascade, which may contribute to symptoms and pathology in Parkinson disease." @default.
- W2029786514 created "2016-06-24" @default.
- W2029786514 creator A5011234589 @default.
- W2029786514 creator A5027965558 @default.
- W2029786514 creator A5036983961 @default.
- W2029786514 creator A5089468570 @default.
- W2029786514 date "2009-12-08" @default.
- W2029786514 modified "2023-09-30" @default.
- W2029786514 title "Brain Arachidonic Acid Cascade Enzymes are Upregulated in a Rat Model of Unilateral Parkinson Disease" @default.
- W2029786514 cites W1573258040 @default.
- W2029786514 cites W1968998365 @default.
- W2029786514 cites W1969357118 @default.
- W2029786514 cites W1981819503 @default.
- W2029786514 cites W1983479763 @default.
- W2029786514 cites W1985091985 @default.
- W2029786514 cites W1989782625 @default.
- W2029786514 cites W1991603311 @default.
- W2029786514 cites W1997940652 @default.
- W2029786514 cites W1998322637 @default.
- W2029786514 cites W2003196491 @default.
- W2029786514 cites W2007740082 @default.
- W2029786514 cites W2008270857 @default.
- W2029786514 cites W2017133239 @default.
- W2029786514 cites W2018154493 @default.
- W2029786514 cites W2023202273 @default.
- W2029786514 cites W2033714165 @default.
- W2029786514 cites W2035400428 @default.
- W2029786514 cites W2036533672 @default.
- W2029786514 cites W2042261016 @default.
- W2029786514 cites W2045281361 @default.
- W2029786514 cites W2046734045 @default.
- W2029786514 cites W2047379678 @default.
- W2029786514 cites W2049733399 @default.
- W2029786514 cites W2050220723 @default.
- W2029786514 cites W2050709677 @default.
- W2029786514 cites W2051958752 @default.
- W2029786514 cites W2055870207 @default.
- W2029786514 cites W2056223162 @default.
- W2029786514 cites W2056402816 @default.
- W2029786514 cites W2060790782 @default.
- W2029786514 cites W2064881079 @default.
- W2029786514 cites W2065000444 @default.
- W2029786514 cites W2066113689 @default.
- W2029786514 cites W2071997617 @default.
- W2029786514 cites W2072855809 @default.
- W2029786514 cites W2073469785 @default.
- W2029786514 cites W2073805066 @default.
- W2029786514 cites W2075394970 @default.
- W2029786514 cites W2077360634 @default.
- W2029786514 cites W2078986708 @default.
- W2029786514 cites W2079903450 @default.
- W2029786514 cites W2082910317 @default.
- W2029786514 cites W2083508426 @default.
- W2029786514 cites W2084506085 @default.
- W2029786514 cites W2085023165 @default.
- W2029786514 cites W2088819818 @default.
- W2029786514 cites W2090142152 @default.
- W2029786514 cites W2110478912 @default.
- W2029786514 cites W2111464898 @default.
- W2029786514 cites W2115477213 @default.
- W2029786514 cites W2117442313 @default.
- W2029786514 cites W2120095464 @default.
- W2029786514 cites W2120412340 @default.
- W2029786514 cites W2124374021 @default.
- W2029786514 cites W2129247157 @default.
- W2029786514 cites W2139921727 @default.
- W2029786514 cites W2143934651 @default.
- W2029786514 cites W2149046471 @default.
- W2029786514 cites W2156292177 @default.
- W2029786514 cites W2161325655 @default.
- W2029786514 cites W2165738847 @default.
- W2029786514 cites W2171688276 @default.
- W2029786514 cites W2261589407 @default.
- W2029786514 cites W2463063858 @default.
- W2029786514 cites W260728179 @default.
- W2029786514 cites W4231395949 @default.
- W2029786514 cites W4361865119 @default.
- W2029786514 cites W49996880 @default.
- W2029786514 doi "https://doi.org/10.1007/s11064-009-0106-6" @default.
- W2029786514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2836388" @default.
- W2029786514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19997776" @default.
- W2029786514 hasPublicationYear "2009" @default.
- W2029786514 type Work @default.
- W2029786514 sameAs 2029786514 @default.
- W2029786514 citedByCount "33" @default.
- W2029786514 countsByYear W20297865142012 @default.
- W2029786514 countsByYear W20297865142013 @default.
- W2029786514 countsByYear W20297865142014 @default.
- W2029786514 countsByYear W20297865142015 @default.
- W2029786514 countsByYear W20297865142016 @default.
- W2029786514 countsByYear W20297865142018 @default.
- W2029786514 countsByYear W20297865142019 @default.
- W2029786514 countsByYear W20297865142020 @default.
- W2029786514 countsByYear W20297865142021 @default.
- W2029786514 countsByYear W20297865142022 @default.
- W2029786514 countsByYear W20297865142023 @default.
- W2029786514 crossrefType "journal-article" @default.
- W2029786514 hasAuthorship W2029786514A5011234589 @default.