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- W2029794037 abstract "metabolites are the true differentiation-inducing factors, but when he analysed the metabolites none had activity and none antagonized the action of DIF itself. The distribution of DIF remains a paradox. The second complication was described 13,,: Jeff Williams (London), who showed that the pre-stalk population, hitherto considered homogeneous, actually consists of three cell types: one is marked by a gene designated 56, one by a gene designated 63, and one does not express either. Williams described how the three populations might cooperate to form the stalk tube of the fruiting body, and provided preliminary data to suggest that the genes 56 and 63 are activated in response to different concentrations of DIF. This would be an exciting result, reminiscent of the genes X and hunchback in Drosophila. And the fact that Dictyosteliunz also has powerful genetics (mutants that are defective in some aspect of development can be maintained as amoebae) may mean that one can now analyse how a single molecule can specify different cell types via extracellular, rather than Antracellular, signalling. The hypothesis of positional information has variously been described (mostly bv those who have not read the original papers) as obvious, meaningless or untestable. This meeting~ held 20 years after the idea was first proposed, provided some direct evidence that positional information is used during development and that it can be analysed at the molecular level." @default.
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- W2029794037 date "1989-01-01" @default.
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- W2029794037 title "Mitosis comes apart" @default.
- W2029794037 doi "https://doi.org/10.1016/0168-9525(89)90067-x" @default.
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