Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029803348> ?p ?o ?g. }
- W2029803348 endingPage "590" @default.
- W2029803348 startingPage "584" @default.
- W2029803348 abstract "1. The aim of this study was to assess whether an excitotoxic insult induced by NMDA may induce an iNOS activity which contributes to the lesion in the rat striatum. 2. For this purpose, rats were perfused with 10 mM NMDA through a microdialysis probe implanted in the left striatum. Microdialysate nitrite content, striatal Ca-independent nitric oxide synthase activity and lesion volume were measured 48 h after NMDA exposure in rats treated with dexamethasone (DXM) (3 mg kg(-1) x 4) or aminoguanidine (AG) (100 mg kg(-1) x 4). 3. A significant increase in microdialysate nitrite content and in the Ca-independent NOS activity was observed 48 h after NMDA infusion. Both these increases were reduced by DXM and AG. The NMDA-induced striatal lesion was also reduced by both treatments. 4. Our results demonstrate that NMDA excitotoxic injury induces a delayed, sustained activation of a Ca-independent NOS activity. This activity is blocked by DXM and AG, strongly suggesting the involvement of iNOS. The fact that AG and DXM reduce the NMDA-elicited lesion suggests that iNOS contributes to the brain damage induced by excitotoxic insult." @default.
- W2029803348 created "2016-06-24" @default.
- W2029803348 creator A5057264297 @default.
- W2029803348 creator A5073989552 @default.
- W2029803348 creator A5078915581 @default.
- W2029803348 creator A5082802774 @default.
- W2029803348 creator A5090247947 @default.
- W2029803348 date "1998-10-01" @default.
- W2029803348 modified "2023-10-05" @default.
- W2029803348 title "iNOS contribution to the NMDA-induced excitotoxic lesion in the rat striatum" @default.
- W2029803348 cites W1490298304 @default.
- W2029803348 cites W1747994692 @default.
- W2029803348 cites W1834041853 @default.
- W2029803348 cites W1969373337 @default.
- W2029803348 cites W1974749007 @default.
- W2029803348 cites W1979283306 @default.
- W2029803348 cites W1980692158 @default.
- W2029803348 cites W1983880247 @default.
- W2029803348 cites W1985221375 @default.
- W2029803348 cites W1990802251 @default.
- W2029803348 cites W1998104086 @default.
- W2029803348 cites W1998565371 @default.
- W2029803348 cites W2001570810 @default.
- W2029803348 cites W2002526073 @default.
- W2029803348 cites W2003281598 @default.
- W2029803348 cites W2004343006 @default.
- W2029803348 cites W2006835697 @default.
- W2029803348 cites W2012066718 @default.
- W2029803348 cites W2012536557 @default.
- W2029803348 cites W2015295078 @default.
- W2029803348 cites W2015848852 @default.
- W2029803348 cites W2016523675 @default.
- W2029803348 cites W2019681590 @default.
- W2029803348 cites W2021117769 @default.
- W2029803348 cites W2023396428 @default.
- W2029803348 cites W2024556319 @default.
- W2029803348 cites W2025061551 @default.
- W2029803348 cites W2027490559 @default.
- W2029803348 cites W2035728527 @default.
- W2029803348 cites W2037506390 @default.
- W2029803348 cites W2037768305 @default.
- W2029803348 cites W2041805349 @default.
- W2029803348 cites W2047362612 @default.
- W2029803348 cites W2051031104 @default.
- W2029803348 cites W2054939193 @default.
- W2029803348 cites W2056258976 @default.
- W2029803348 cites W2063537428 @default.
- W2029803348 cites W2076043812 @default.
- W2029803348 cites W2077641692 @default.
- W2029803348 cites W2077824574 @default.
- W2029803348 cites W2079806280 @default.
- W2029803348 cites W2082724267 @default.
- W2029803348 cites W2088193206 @default.
- W2029803348 cites W2093636423 @default.
- W2029803348 cites W2125582135 @default.
- W2029803348 cites W2137726937 @default.
- W2029803348 cites W2157982135 @default.
- W2029803348 cites W2467698722 @default.
- W2029803348 cites W258569422 @default.
- W2029803348 cites W4293247451 @default.
- W2029803348 doi "https://doi.org/10.1038/sj.bjp.0702119" @default.
- W2029803348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565656" @default.
- W2029803348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9806344" @default.
- W2029803348 hasPublicationYear "1998" @default.
- W2029803348 type Work @default.
- W2029803348 sameAs 2029803348 @default.
- W2029803348 citedByCount "26" @default.
- W2029803348 countsByYear W20298033482013 @default.
- W2029803348 countsByYear W20298033482014 @default.
- W2029803348 countsByYear W20298033482015 @default.
- W2029803348 countsByYear W20298033482018 @default.
- W2029803348 crossrefType "journal-article" @default.
- W2029803348 hasAuthorship W2029803348A5057264297 @default.
- W2029803348 hasAuthorship W2029803348A5073989552 @default.
- W2029803348 hasAuthorship W2029803348A5078915581 @default.
- W2029803348 hasAuthorship W2029803348A5082802774 @default.
- W2029803348 hasAuthorship W2029803348A5090247947 @default.
- W2029803348 hasBestOaLocation W20298033481 @default.
- W2029803348 hasConcept C126322002 @default.
- W2029803348 hasConcept C134018914 @default.
- W2029803348 hasConcept C142724271 @default.
- W2029803348 hasConcept C170493617 @default.
- W2029803348 hasConcept C185592680 @default.
- W2029803348 hasConcept C2776706248 @default.
- W2029803348 hasConcept C2777622882 @default.
- W2029803348 hasConcept C2777896816 @default.
- W2029803348 hasConcept C2780062018 @default.
- W2029803348 hasConcept C2781012912 @default.
- W2029803348 hasConcept C2781156865 @default.
- W2029803348 hasConcept C42219234 @default.
- W2029803348 hasConcept C50156730 @default.
- W2029803348 hasConcept C513476851 @default.
- W2029803348 hasConcept C515207424 @default.
- W2029803348 hasConcept C519581460 @default.
- W2029803348 hasConcept C529278444 @default.
- W2029803348 hasConcept C55493867 @default.
- W2029803348 hasConcept C61174792 @default.
- W2029803348 hasConcept C67018056 @default.