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- W2029803399 abstract "Abstract Blood and tissues were taken for enzyme studies from rats which were raised on a selenium- and vitamin E-deficient diet or this diet containing vitamin E and/or selenium. Plasma levels of enzymes which are found in high concentrations in the liver were significantly higher in rats with liver necrosis (selenium and vitamin E deficient). Creatine phosphokinase (CPK), an enzyme found in high levels in muscle, was not affected significantly in plasma of vitamin E- and/or selenium-deficient rats. The activities of aryl sulfatase, β-glucuronidase, the autolytic activity, and the thiobarbituric acid index were significantly higher, and lactic dehydrogenase (LDH) levels were significantly lower in livers of rats with liver necrosis. The proteolytic activity, acid phosphatase, and glutamic-oxalacetic transaminase (GOT) levels were not affected in liver of vitamin E- and/or selenium-deficient rats nor were GOT, LDH, aryl sulfatase, or peroxidase levels affected in the heart, kidney, or muscle. The results indicate that plasma levels of isocitrate dehydrogenase, 6-phosphogluconate dehydrogenase, glutamic dehydrogenase, or ornithine carbamyl transferase (probably the most sensitive) could be used to detect liver damage, whereas CPK is the enzyme of choice for detecting muscle damage." @default.
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- W2029803399 date "1971-12-01" @default.
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- W2029803399 title "Enzyme changes in rats with terminal liver necrosis due to vitamin E and selenium deficiencies" @default.
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- W2029803399 doi "https://doi.org/10.1016/0006-2944(71)90060-3" @default.
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