FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029804518> ?p ?o ?g. }

• W2029804518 endingPage "8765" @default.
• W2029804518 startingPage "8760" @default.
• W2029804518 abstract "Development of cancer receptor-specific gold nanoparticles will allow efficient targeting/optimum retention of engineered gold nanoparticles within tumors and thus provide synergistic advantages in oncology as it relates to molecular imaging and therapy. Bombesin (BBN) peptides have demonstrated high affinity toward gastrin-releasing peptide (GRP) receptors in vivo that are overexpressed in prostate, breast, and small-cell lung carcinoma. We have synthesized a library of GRP receptor-avid nanoplatforms by conjugating gold nanoparticles (AuNPs) with BBN peptides. Cellular interactions and binding affinities (IC(50)) of AuNP-BBN conjugates toward GRP receptors on human prostate cancer cells have been investigated in detail. In vivo studies using AuNP-BBN and its radiolabeled surrogate (198)AuNP-BBN, exhibiting high binding affinity (IC(50) in microgram ranges), provide unequivocal evidence that AuNP-BBN constructs are GRP-receptor-specific showing accumulation with high selectivity in GRP-receptor-rich pancreatic acne in normal mice and also in tumors in prostate-tumor-bearing, severe combined immunodeficient mice. The i.p. mode of delivery has been found to be efficient as AuNP-BBN conjugates showed reduced RES organ uptake with concomitant increase in uptake at tumor targets. The selective uptake of this new generation of GRP-receptor-specific AuNP-BBN peptide analogs has demonstrated realistic clinical potential in molecular imaging via x-ray computed tomography techniques as the contrast numbers in prostate tumor sites are severalfold higher as compared to the pretreatment group (Hounsfield unit = 150)." @default.
• W2029804518 created "2016-06-24" @default.
• W2029804518 creator A5000117158 @default.
• W2029804518 creator A5000147051 @default.
• W2029804518 creator A5004651450 @default.
• W2029804518 creator A5013536974 @default.
• W2029804518 creator A5017475559 @default.
• W2029804518 creator A5018939644 @default.
• W2029804518 creator A5022268230 @default.
• W2029804518 creator A5028533016 @default.
• W2029804518 creator A5032745557 @default.
• W2029804518 creator A5036871553 @default.
• W2029804518 creator A5038368416 @default.
• W2029804518 creator A5042065663 @default.
• W2029804518 creator A5048339704 @default.
• W2029804518 creator A5053344475 @default.
• W2029804518 creator A5057087630 @default.
• W2029804518 creator A5066068081 @default.
• W2029804518 creator A5085292862 @default.
• W2029804518 date "2010-04-21" @default.
• W2029804518 modified "2023-10-18" @default.
• W2029804518 title "Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity" @default.
• W2029804518 cites W107213678 @default.
• W2029804518 cites W1977535787 @default.
• W2029804518 cites W1978699375 @default.
• W2029804518 cites W1983466982 @default.
• W2029804518 cites W1983792141 @default.
• W2029804518 cites W1984287992 @default.
• W2029804518 cites W1984408853 @default.
• W2029804518 cites W1992685120 @default.
• W2029804518 cites W1995734581 @default.
• W2029804518 cites W1998466442 @default.
• W2029804518 cites W2012370849 @default.
• W2029804518 cites W2012394652 @default.
• W2029804518 cites W2014914090 @default.
• W2029804518 cites W2032760352 @default.
• W2029804518 cites W2038548342 @default.
• W2029804518 cites W2038781049 @default.
• W2029804518 cites W2041806531 @default.
• W2029804518 cites W2062846011 @default.
• W2029804518 cites W2063472419 @default.
• W2029804518 cites W2114562672 @default.
• W2029804518 cites W2121170935 @default.
• W2029804518 cites W2121811064 @default.
• W2029804518 cites W2125753084 @default.
• W2029804518 cites W2129360146 @default.
• W2029804518 cites W2132528779 @default.
• W2029804518 cites W2145363935 @default.
• W2029804518 cites W2156429223 @default.
• W2029804518 cites W2161085277 @default.
• W2029804518 cites W2170829363 @default.
• W2029804518 cites W2322390594 @default.
• W2029804518 cites W2395057684 @default.
• W2029804518 doi "https://doi.org/10.1073/pnas.1002143107" @default.
• W2029804518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2889350" @default.
• W2029804518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20410458" @default.
• W2029804518 hasPublicationYear "2010" @default.
• W2029804518 type Work @default.
• W2029804518 sameAs 2029804518 @default.
• W2029804518 citedByCount "275" @default.
• W2029804518 countsByYear W20298045182012 @default.
• W2029804518 countsByYear W20298045182013 @default.
• W2029804518 countsByYear W20298045182014 @default.
• W2029804518 countsByYear W20298045182015 @default.
• W2029804518 countsByYear W20298045182016 @default.
• W2029804518 countsByYear W20298045182017 @default.
• W2029804518 countsByYear W20298045182018 @default.
• W2029804518 countsByYear W20298045182019 @default.
• W2029804518 countsByYear W20298045182020 @default.
• W2029804518 countsByYear W20298045182021 @default.
• W2029804518 countsByYear W20298045182022 @default.
• W2029804518 countsByYear W20298045182023 @default.
• W2029804518 crossrefType "journal-article" @default.
• W2029804518 hasAuthorship W2029804518A5000117158 @default.
• W2029804518 hasAuthorship W2029804518A5000147051 @default.
• W2029804518 hasAuthorship W2029804518A5004651450 @default.
• W2029804518 hasAuthorship W2029804518A5013536974 @default.
• W2029804518 hasAuthorship W2029804518A5017475559 @default.
• W2029804518 hasAuthorship W2029804518A5018939644 @default.
• W2029804518 hasAuthorship W2029804518A5022268230 @default.
• W2029804518 hasAuthorship W2029804518A5028533016 @default.
• W2029804518 hasAuthorship W2029804518A5032745557 @default.
• W2029804518 hasAuthorship W2029804518A5036871553 @default.
• W2029804518 hasAuthorship W2029804518A5038368416 @default.
• W2029804518 hasAuthorship W2029804518A5042065663 @default.
• W2029804518 hasAuthorship W2029804518A5048339704 @default.
• W2029804518 hasAuthorship W2029804518A5053344475 @default.
• W2029804518 hasAuthorship W2029804518A5057087630 @default.
• W2029804518 hasAuthorship W2029804518A5066068081 @default.
• W2029804518 hasAuthorship W2029804518A5085292862 @default.
• W2029804518 hasBestOaLocation W20298045181 @default.
• W2029804518 hasConcept C104819515 @default.
• W2029804518 hasConcept C118303440 @default.
• W2029804518 hasConcept C121608353 @default.
• W2029804518 hasConcept C12554922 @default.
• W2029804518 hasConcept C126322002 @default.
• W2029804518 hasConcept C136339569 @default.
• W2029804518 hasConcept C150903083 @default.

• next