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W2029808217 abstract "Novel, structurally modified potential mimics of the second messenger d-myo-inositol 1,4,5-trisphosphate, based on the biologically active regioisomer d-myo-inositol 1,4,6-trisphosphate, were synthesised. dl-5-O-Benzyl-1,4,6-tri-O-p-methoxybenzyl-myo-inositol was the key intermediate for the preparation of the following compounds: dl-3-deoxy-, dl-3-deoxy-2-O-methyl-, dl-3-O-(2-hydroxyethyl)-, dl-3-O-(3-hydroxypropyl)- and dl-3-O-(4-hydroxybutyl)-myo-inositol 1,4,6-trisphosphate. dl-1,4,6-Tri-O -allyl-5-O-benzyl-myo-inositol was used to prepare dl-2-O-methyl-myo-inositol 1,4,6-trisphosphate. Deoxy-compounds were prepared by reduction of the corresponding tosylated intermediate using Super Hydride. The hydroxyalkyl groups were introduced at the C-3 of myo-inositol using the corresponding benzyl protected hydroxy alkyl bromide via the cis-2,3-O-dibutylstannylene acetal.Methylation and benzylation at C-2 was accomplished using methyl iodide and benzyl bromide, respectively, in the presence of sodium hydride. Deblocking of p-methoxybenzyl groups was accomplished with TFA in dichloromethane and the allyl groups were removed by isomerisation to the cis-prop-1-enyl derivative, which was hydrolysed under acidic conditions to give the corresponding 1,4,6-triol.The 1,4,6-triols were phosphitylated with the P(III) reagent bis(benzyloxy)(diisopropylamino)phosphine in the presence of 1H-tetrazole then oxidised with 3-chloroperoxybenzoic acid followed by deblocking by hydrogenolysis to give dl-2-O-methyl-, dl-3-O-deoxy-, dl-3-O-deoxy-2-O-methyl-, dl-3-O-(2-hydroxyethyl)-, dl-3-O-(3-hydroxypropyl)- and dl-3-O-(4-hydroxybutyl)-myo-inositol 1,4,6-trisphosphate, respectively." @default.
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W2029808217 date "1992-01-01" @default.
W2029808217 modified "2023-09-26" @default.
W2029808217 title "P39. Influence of age and site of bone response to HRT" @default.
W2029808217 doi "https://doi.org/10.1016/8756-3282(92)90442-y" @default.
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