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- W2029808259 abstract "Abstract Both the sickle cell trait (HbAS) and α + ‐thalassaemia are common in many tropical areas. While their individual haematological effects are well described, few studies describe their effects when inherited together. We present data from the Kenyan coast, which suggest that HbAS and α + ‐thalassaemia may interact to produce specific effects on haematological parameters. Overall, the difference in Hb concentrations between non‐thalassaemics ( α α / α α ) and α + ‐thalassaemia homozygotes (− α /− α ) was greater in non‐HbAS (HbAA) (0·63 g/dl) than in HbAS children (0·25 g/dl). HbAS also ameliorated both the reduced mean cell volume and mean cell haemoglobin normally associated with the − α /− α genotype. Potential mechanisms and implications are discussed." @default.
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- W2029808259 date "2006-02-10" @default.
- W2029808259 modified "2023-10-18" @default.
- W2029808259 title "Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters" @default.
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- W2029808259 doi "https://doi.org/10.1111/j.1365-2141.2006.06006.x" @default.
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