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• W2029808323 abstract "Regional patterns of protein synthesis were examined in rat cortex made ischemic by the occlusion of the right common carotid and middle cerebral arteries. At 2 h of ischemia, proteins were pulse labeled with intracortical injections of a mixture of [ 3 H]leucine, [ 3 H]isoleucine, and [ 3 H]proline. Newly synthesized proteins were analyzed by two-dimensional gel fluorography, and the results correlated with local CBF, measured with [ 14 C]iodoantipyrine as tracer. Small blood flow reductions (CBF = 50–80 ml 100 g −1 min −1 ) were accompanied by a modest inhibition in synthesis of many proteins and a marked increase in one protein (M r 27,000). With further reduction in blood flow (CBF = 40 ml 100 g −1 min −1 ), synthesis became limited to a small group of proteins (M r 27,000, 34,000, 73,000, 79,000, and actin) including two new polypeptides (M r 55,000 and 70,000). Severe ischemia (CBF = 15–25 ml 100 g −1 min −1 ) caused the isoelectric modification of several proteins (M r 44,000, 55,000, and 70,000) and induced synthesis of another protein (M r 40,000). Two polypeptides (M r 27,000 and 70,000) dominated residual protein synthesis in severe ischemia. The changes in protein synthesis induced by different grades of ischemia most likely comprise a variation of the so-called “heat shock” or “stress” response found in all eukaryotic cells subjected to adverse conditions. Since heat shock genes are known to confer partial protection against anoxia and a variety of other noxious insults, their induction may be a factor in limiting the extent of ischemic tissue damage." @default.
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• W2029808323 date "1986-06-01" @default.
• W2029808323 modified "2023-09-29" @default.
• W2029808323 title "Selective Gene Expression in Focal Cerebral Ischemia" @default.
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• W2029808323 doi "https://doi.org/10.1038/jcbfm.1986.48" @default.
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