FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029809098> ?p ?o ?g. }

• W2029809098 endingPage "732" @default.
• W2029809098 startingPage "724" @default.
• W2029809098 abstract "Nonmelanoma skin cancer is the most prevalent cancer in the United States with ∼1.25 million new cases diagnosed each year. Cyclooxygenase-2 (COX-2) expression is commonly elevated in these and other epithelial tumors. Cyclooxygenases metabolize arachidonic acid to prostaglandins, which promote growth and survival of tumor cells. COX-2 also metabolizes endocannabinoids forming prostaglandin-ethanolamides (PG-EA); however, the role of these lipid molecules in tumor cell survival is unclear. The goal of this research is to determine if the metabolic products of COX-2 contribute to endocannabinoid-induced cell death. Anandamide [also known as arachidonyl ethanolamide (AEA)] induced cell death in the COX-2 overexpressing squamous carcinoma cell line JWF2. In contrast, AEA did not initiate cell death in HaCaT keratinocytes, which express low basal levels of COX-2. Resistance to AEA-mediated cell death in HaCaT cells was reversed by overexpressing COX-2 in these cells. Next, ELISA assays were carried out to identify prostaglandins involved in AEA-mediated cell death. D-type prostaglandins were predominantly formed in AEA-exposed JWF2 cells although significant increases in E- and F-type prostaglandins were also seen. Cells were then treated with various prostaglandins or PG-EA to determine the contribution of each to AEA-induced cell death. PGD2 and PGD2-EA were found to be cytotoxic to JWF2 keratinocytes and the PGD2 dehydration products, PGJ2 and 15-deoxy Δ12,14 PGJ2, were also potent inducers of cell death. These results suggest that AEA selectively induces cell death in tumorigenic keratinocytes due to COX-2 overexpression and the resulting metabolism of AEA to cytotoxic prostaglandins. © 2009 Wiley-Liss, Inc." @default.
• W2029809098 created "2016-06-24" @default.
• W2029809098 creator A5082921430 @default.
• W2029809098 date "2009-08-01" @default.
• W2029809098 modified "2023-10-14" @default.
• W2029809098 title "Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes" @default.
• W2029809098 cites W1938950485 @default.
• W2029809098 cites W1966440880 @default.
• W2029809098 cites W1969338731 @default.
• W2029809098 cites W1972605770 @default.
• W2029809098 cites W1980410293 @default.
• W2029809098 cites W2035376023 @default.
• W2029809098 cites W2039494109 @default.
• W2029809098 cites W2043103956 @default.
• W2029809098 cites W2046892501 @default.
• W2029809098 cites W2049772907 @default.
• W2029809098 cites W2059303949 @default.
• W2029809098 cites W2062752021 @default.
• W2029809098 cites W2063837435 @default.
• W2029809098 cites W2100919593 @default.
• W2029809098 cites W2113204364 @default.
• W2029809098 cites W2114168966 @default.
• W2029809098 cites W2115482306 @default.
• W2029809098 cites W2119551996 @default.
• W2029809098 cites W2122802846 @default.
• W2029809098 cites W2125456556 @default.
• W2029809098 cites W2129510413 @default.
• W2029809098 cites W2130876808 @default.
• W2029809098 cites W2141551684 @default.
• W2029809098 cites W2149301267 @default.
• W2029809098 cites W2168147961 @default.
• W2029809098 cites W2170810801 @default.
• W2029809098 cites W4239769024 @default.
• W2029809098 doi "https://doi.org/10.1002/mc.20515" @default.
• W2029809098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19148897" @default.
• W2029809098 hasPublicationYear "2009" @default.
• W2029809098 type Work @default.
• W2029809098 sameAs 2029809098 @default.
• W2029809098 citedByCount "49" @default.
• W2029809098 countsByYear W20298090982012 @default.
• W2029809098 countsByYear W20298090982013 @default.
• W2029809098 countsByYear W20298090982014 @default.
• W2029809098 countsByYear W20298090982015 @default.
• W2029809098 countsByYear W20298090982016 @default.
• W2029809098 countsByYear W20298090982017 @default.
• W2029809098 countsByYear W20298090982018 @default.
• W2029809098 countsByYear W20298090982019 @default.
• W2029809098 countsByYear W20298090982020 @default.
• W2029809098 countsByYear W20298090982021 @default.
• W2029809098 countsByYear W20298090982022 @default.
• W2029809098 countsByYear W20298090982023 @default.
• W2029809098 crossrefType "journal-article" @default.
• W2029809098 hasAuthorship W2029809098A5082921430 @default.
• W2029809098 hasConcept C118995209 @default.
• W2029809098 hasConcept C148001335 @default.
• W2029809098 hasConcept C1491633281 @default.
• W2029809098 hasConcept C170493617 @default.
• W2029809098 hasConcept C181199279 @default.
• W2029809098 hasConcept C190283241 @default.
• W2029809098 hasConcept C2776352991 @default.
• W2029809098 hasConcept C2777361909 @default.
• W2029809098 hasConcept C2778078955 @default.
• W2029809098 hasConcept C2778938600 @default.
• W2029809098 hasConcept C2779783865 @default.
• W2029809098 hasConcept C2780664492 @default.
• W2029809098 hasConcept C31573885 @default.
• W2029809098 hasConcept C46721173 @default.
• W2029809098 hasConcept C502942594 @default.
• W2029809098 hasConcept C54355233 @default.
• W2029809098 hasConcept C55493867 @default.
• W2029809098 hasConcept C81885089 @default.
• W2029809098 hasConcept C86803240 @default.
• W2029809098 hasConcept C95444343 @default.
• W2029809098 hasConceptScore W2029809098C118995209 @default.
• W2029809098 hasConceptScore W2029809098C148001335 @default.
• W2029809098 hasConceptScore W2029809098C1491633281 @default.
• W2029809098 hasConceptScore W2029809098C170493617 @default.
• W2029809098 hasConceptScore W2029809098C181199279 @default.
• W2029809098 hasConceptScore W2029809098C190283241 @default.
• W2029809098 hasConceptScore W2029809098C2776352991 @default.
• W2029809098 hasConceptScore W2029809098C2777361909 @default.
• W2029809098 hasConceptScore W2029809098C2778078955 @default.
• W2029809098 hasConceptScore W2029809098C2778938600 @default.
• W2029809098 hasConceptScore W2029809098C2779783865 @default.
• W2029809098 hasConceptScore W2029809098C2780664492 @default.
• W2029809098 hasConceptScore W2029809098C31573885 @default.
• W2029809098 hasConceptScore W2029809098C46721173 @default.
• W2029809098 hasConceptScore W2029809098C502942594 @default.
• W2029809098 hasConceptScore W2029809098C54355233 @default.
• W2029809098 hasConceptScore W2029809098C55493867 @default.
• W2029809098 hasConceptScore W2029809098C81885089 @default.
• W2029809098 hasConceptScore W2029809098C86803240 @default.
• W2029809098 hasConceptScore W2029809098C95444343 @default.
• W2029809098 hasIssue "8" @default.
• W2029809098 hasLocation W20298090981 @default.
• W2029809098 hasLocation W20298090982 @default.
• W2029809098 hasOpenAccess W2029809098 @default.
• W2029809098 hasPrimaryLocation W20298090981 @default.

• next