Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029830313> ?p ?o ?g. }
- W2029830313 abstract "Human magphinin proteins are translation products of differentially spliced transcripts from the 5' region of the human trophinin gene (TRO), whose 3' region encodes trophinin, a unique cell adhesion molecule involved in human embryo implantation. Magphinins belong to the MAGE (melanoma-associated antigen) family, and a previous study of mouse magphinins showed their expression in male and female germ cells, suggesting a role in germ cell development. Here, we characterized the structure and subcellular localization of human magphinins. Confocal microscopy analysis of ectopically expressed magphinins revealed that magphinin-alpha and -beta localize in the cytoplasm, whereas magphinin-gamma lacking the peptide encoded by exon-3 is nuclear. Following Triton X-100 extraction, DNA digestion, and high salt extraction magphinin-gamma remained nuclear, suggesting strong association with the nuclear matrix. A series of magphinin-gamma deletion mutants were generated and assayed for localization, which showed that the N-terminal region of the MAGE homology domain is necessary for nuclear localization. When magphinin-gamma was expressed in NIH3T3 cells, cells underwent G1 arrest. These results suggest that human magphinin-gamma inhibits cell cycle progression through nuclear activity." @default.
- W2029830313 created "2016-06-24" @default.
- W2029830313 creator A5006762365 @default.
- W2029830313 creator A5015495682 @default.
- W2029830313 creator A5019397425 @default.
- W2029830313 creator A5036364980 @default.
- W2029830313 creator A5047300224 @default.
- W2029830313 creator A5053769726 @default.
- W2029830313 creator A5056487212 @default.
- W2029830313 creator A5058098685 @default.
- W2029830313 creator A5086465836 @default.
- W2029830313 creator A5073240516 @default.
- W2029830313 date "2008-01-01" @default.
- W2029830313 modified "2023-09-27" @default.
- W2029830313 title "Nuclear localization of magphinins, alternative splicing products of the human trophinin gene" @default.
- W2029830313 cites W1541170357 @default.
- W2029830313 cites W1589532501 @default.
- W2029830313 cites W1622325070 @default.
- W2029830313 cites W1964946285 @default.
- W2029830313 cites W1966593231 @default.
- W2029830313 cites W1976647192 @default.
- W2029830313 cites W1978032395 @default.
- W2029830313 cites W1979216378 @default.
- W2029830313 cites W1983184525 @default.
- W2029830313 cites W1991745061 @default.
- W2029830313 cites W1994104851 @default.
- W2029830313 cites W1999203392 @default.
- W2029830313 cites W2006211612 @default.
- W2029830313 cites W2010318629 @default.
- W2029830313 cites W2014515633 @default.
- W2029830313 cites W2025258456 @default.
- W2029830313 cites W2026511788 @default.
- W2029830313 cites W2028603863 @default.
- W2029830313 cites W2034514059 @default.
- W2029830313 cites W2036708294 @default.
- W2029830313 cites W2037739709 @default.
- W2029830313 cites W2039135332 @default.
- W2029830313 cites W2039603397 @default.
- W2029830313 cites W2042169129 @default.
- W2029830313 cites W2044568075 @default.
- W2029830313 cites W2047672708 @default.
- W2029830313 cites W2056249471 @default.
- W2029830313 cites W2059479770 @default.
- W2029830313 cites W2070481770 @default.
- W2029830313 cites W2070933780 @default.
- W2029830313 cites W2076716879 @default.
- W2029830313 cites W2080332106 @default.
- W2029830313 cites W2081530732 @default.
- W2029830313 cites W2105318015 @default.
- W2029830313 cites W2111297890 @default.
- W2029830313 cites W2113717339 @default.
- W2029830313 cites W2137998934 @default.
- W2029830313 cites W2141942950 @default.
- W2029830313 cites W2153781529 @default.
- W2029830313 cites W2161799830 @default.
- W2029830313 cites W2168319336 @default.
- W2029830313 cites W2168836733 @default.
- W2029830313 cites W2299200084 @default.
- W2029830313 cites W2339422997 @default.
- W2029830313 doi "https://doi.org/10.1002/jcb.21446" @default.
- W2029830313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17559068" @default.
- W2029830313 hasPublicationYear "2008" @default.
- W2029830313 type Work @default.
- W2029830313 sameAs 2029830313 @default.
- W2029830313 citedByCount "7" @default.
- W2029830313 countsByYear W20298303132012 @default.
- W2029830313 countsByYear W20298303132014 @default.
- W2029830313 countsByYear W20298303132021 @default.
- W2029830313 crossrefType "journal-article" @default.
- W2029830313 hasAuthorship W2029830313A5006762365 @default.
- W2029830313 hasAuthorship W2029830313A5015495682 @default.
- W2029830313 hasAuthorship W2029830313A5019397425 @default.
- W2029830313 hasAuthorship W2029830313A5036364980 @default.
- W2029830313 hasAuthorship W2029830313A5047300224 @default.
- W2029830313 hasAuthorship W2029830313A5053769726 @default.
- W2029830313 hasAuthorship W2029830313A5056487212 @default.
- W2029830313 hasAuthorship W2029830313A5058098685 @default.
- W2029830313 hasAuthorship W2029830313A5073240516 @default.
- W2029830313 hasAuthorship W2029830313A5086465836 @default.
- W2029830313 hasConcept C104317684 @default.
- W2029830313 hasConcept C105686024 @default.
- W2029830313 hasConcept C153911025 @default.
- W2029830313 hasConcept C186435350 @default.
- W2029830313 hasConcept C190062978 @default.
- W2029830313 hasConcept C2776879804 @default.
- W2029830313 hasConcept C2780114586 @default.
- W2029830313 hasConcept C29512474 @default.
- W2029830313 hasConcept C36823959 @default.
- W2029830313 hasConcept C49805395 @default.
- W2029830313 hasConcept C54355233 @default.
- W2029830313 hasConcept C54458228 @default.
- W2029830313 hasConcept C67705224 @default.
- W2029830313 hasConcept C83640560 @default.
- W2029830313 hasConcept C86339819 @default.
- W2029830313 hasConcept C86803240 @default.
- W2029830313 hasConcept C95444343 @default.
- W2029830313 hasConceptScore W2029830313C104317684 @default.
- W2029830313 hasConceptScore W2029830313C105686024 @default.
- W2029830313 hasConceptScore W2029830313C153911025 @default.
- W2029830313 hasConceptScore W2029830313C186435350 @default.