Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029834781> ?p ?o ?g. }
- W2029834781 endingPage "10387" @default.
- W2029834781 startingPage "10382" @default.
- W2029834781 abstract "The formation of insoluble proteinaceous deposits is characteristic of many diseases which are collectively known as amyloidosis. There is very little molecular-level structural information available regarding the amyloid deposits due to the fact that the constituent proteins are insoluble and noncrystalline. Therefore, traditional protein structure determination methods such as solution NMR and X-ray crystallography are not applicable. We report herein the application of the solid-state NMR technique rotational resonance (R2) to the accurate measurement of carbon-to-carbon distances in the amyloid formed from a synthetic fragment (H2N-LeuMetValGlyGlyValValIleAla-CO2H) of the amyloid-forming protein of Alzheimer's disease (AD). This sequence has been implicated in the initiation of amyloid formation. Two distances measured by R2 indicate that an unusual structure, probably involving a cis amide bond, is present in the aggregated peptide amyloid. This structure is incompatible with the accepted models of fibril structure. A relationship between this structure and the stability of the amyloid is proposed." @default.
- W2029834781 created "2016-06-24" @default.
- W2029834781 creator A5000269609 @default.
- W2029834781 creator A5005020605 @default.
- W2029834781 creator A5025077855 @default.
- W2029834781 creator A5051330133 @default.
- W2029834781 creator A5062442368 @default.
- W2029834781 creator A5070172780 @default.
- W2029834781 date "1991-10-01" @default.
- W2029834781 modified "2023-10-16" @default.
- W2029834781 title "An unusual peptide conformation may precipitate amyloid formation in Alzheimer's disease: application of solid-state NMR to the determination of protein secondary structure" @default.
- W2029834781 cites W1480950303 @default.
- W2029834781 cites W1515357602 @default.
- W2029834781 cites W1593001894 @default.
- W2029834781 cites W1966235885 @default.
- W2029834781 cites W1973151662 @default.
- W2029834781 cites W1978892474 @default.
- W2029834781 cites W1983769531 @default.
- W2029834781 cites W1992748959 @default.
- W2029834781 cites W1994595152 @default.
- W2029834781 cites W2001459021 @default.
- W2029834781 cites W2006817353 @default.
- W2029834781 cites W2007456096 @default.
- W2029834781 cites W2007738721 @default.
- W2029834781 cites W2013833879 @default.
- W2029834781 cites W2015671244 @default.
- W2029834781 cites W2017643275 @default.
- W2029834781 cites W2018561446 @default.
- W2029834781 cites W2021312533 @default.
- W2029834781 cites W2030749300 @default.
- W2029834781 cites W2030825429 @default.
- W2029834781 cites W2038701321 @default.
- W2029834781 cites W2046847750 @default.
- W2029834781 cites W2049227203 @default.
- W2029834781 cites W2049535318 @default.
- W2029834781 cites W2050513584 @default.
- W2029834781 cites W2052702212 @default.
- W2029834781 cites W2059457068 @default.
- W2029834781 cites W2060816193 @default.
- W2029834781 cites W2071691905 @default.
- W2029834781 cites W2075610076 @default.
- W2029834781 cites W2077140822 @default.
- W2029834781 cites W2084627682 @default.
- W2029834781 cites W2087406006 @default.
- W2029834781 cites W2094437767 @default.
- W2029834781 cites W2111249363 @default.
- W2029834781 cites W2111940972 @default.
- W2029834781 cites W2949858665 @default.
- W2029834781 cites W4233736380 @default.
- W2029834781 cites W4252772420 @default.
- W2029834781 cites W430316297 @default.
- W2029834781 doi "https://doi.org/10.1021/bi00107a004" @default.
- W2029834781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1931962" @default.
- W2029834781 hasPublicationYear "1991" @default.
- W2029834781 type Work @default.
- W2029834781 sameAs 2029834781 @default.
- W2029834781 citedByCount "90" @default.
- W2029834781 countsByYear W20298347812013 @default.
- W2029834781 countsByYear W20298347812014 @default.
- W2029834781 countsByYear W20298347812015 @default.
- W2029834781 countsByYear W20298347812016 @default.
- W2029834781 countsByYear W20298347812018 @default.
- W2029834781 countsByYear W20298347812019 @default.
- W2029834781 countsByYear W20298347812021 @default.
- W2029834781 crossrefType "journal-article" @default.
- W2029834781 hasAuthorship W2029834781A5000269609 @default.
- W2029834781 hasAuthorship W2029834781A5005020605 @default.
- W2029834781 hasAuthorship W2029834781A5025077855 @default.
- W2029834781 hasAuthorship W2029834781A5051330133 @default.
- W2029834781 hasAuthorship W2029834781A5062442368 @default.
- W2029834781 hasAuthorship W2029834781A5070172780 @default.
- W2029834781 hasConcept C121332964 @default.
- W2029834781 hasConcept C12554922 @default.
- W2029834781 hasConcept C142724271 @default.
- W2029834781 hasConcept C153202636 @default.
- W2029834781 hasConcept C177907266 @default.
- W2029834781 hasConcept C179104552 @default.
- W2029834781 hasConcept C185592680 @default.
- W2029834781 hasConcept C27523624 @default.
- W2029834781 hasConcept C2777633098 @default.
- W2029834781 hasConcept C2778112365 @default.
- W2029834781 hasConcept C2778439535 @default.
- W2029834781 hasConcept C2779134260 @default.
- W2029834781 hasConcept C2779281246 @default.
- W2029834781 hasConcept C2779951007 @default.
- W2029834781 hasConcept C2994168385 @default.
- W2029834781 hasConcept C3019447875 @default.
- W2029834781 hasConcept C31705614 @default.
- W2029834781 hasConcept C46141821 @default.
- W2029834781 hasConcept C47701112 @default.
- W2029834781 hasConcept C502032728 @default.
- W2029834781 hasConcept C55493867 @default.
- W2029834781 hasConcept C62614982 @default.
- W2029834781 hasConcept C71924100 @default.
- W2029834781 hasConcept C8010536 @default.
- W2029834781 hasConcept C86803240 @default.
- W2029834781 hasConceptScore W2029834781C121332964 @default.
- W2029834781 hasConceptScore W2029834781C12554922 @default.