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- W2029846811 abstract "Assessing molecular persistent or minimal residual disease (PD/MRD) in childhood Burkitt lymphoma (BL) is challenging because access to original tumor is usually needed to design patient-specific primers (PSPs). Because BL is characterized by rearranged immunoglobulin heavy chain (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mtext>I</mml:mtext><mml:mtext>g</mml:mtext><mml:msub><mml:mtext>V</mml:mtext><mml:mtext>H</mml:mtext></mml:msub></mml:mrow></mml:math>) genes,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mtext>I</mml:mtext><mml:mtext>g</mml:mtext><mml:msub><mml:mtext>V</mml:mtext><mml:mtext>H</mml:mtext></mml:msub></mml:mrow></mml:math>primer pools from<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mtext>I</mml:mtext><mml:mtext>g</mml:mtext><mml:msub><mml:mtext>V</mml:mtext><mml:mrow><mml:mtext>H1</mml:mtext></mml:mrow></mml:msub><mml:mrow><mml:mtext>–I</mml:mtext></mml:mrow><mml:mtext>g</mml:mtext><mml:msub><mml:mtext>V</mml:mtext><mml:mrow><mml:mtext>H</mml:mtext><mml:mn>7</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>regions were tested to detect PD/MRD, thus eliminating the need for original tumor. The focus of the current study was to assess the feasibility of using<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mtext>I</mml:mtext><mml:mtext>g</mml:mtext><mml:msub><mml:mtext>V</mml:mtext><mml:mtext>H</mml:mtext></mml:msub></mml:mrow></mml:math>primer pools to detect disease in clinical specimens. Fourteen children diagnosed with B-NHL had follow-up repository specimens available to assess PD/MRD. Of the 14 patients, 12 were PD/MRD negative after 2 months of therapy and remained in remission at the end of therapy; 2/14 patients were PD/MRD positive at 2-3 months and later relapsed. PSP-based assays from these 14 patients showed 100% concordance with the current assay. This feasibility study warrants further investigation to assess PD/MRD using<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mtext>I</mml:mtext><mml:mtext>g</mml:mtext><mml:msub><mml:mtext>V</mml:mtext><mml:mtext>H</mml:mtext></mml:msub></mml:mrow></mml:math>primer pools, which could have clinical significance as a real-time assessment tool to monitor pediatric BL and possibly other B-cell non-Hodgkin lymphoma therapy." @default.
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- W2029846811 date "2009-01-01" @default.
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- W2029846811 title "Screening for Residual Disease in Pediatric Burkitt Lymphoma Using Consensus Primer Pools" @default.
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