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- W2029850670 abstract "The main objective of these studies is to quantitatively estimate pK variations of individual amide bonds as a function of the ionization state of end groups in peptides, determined on measuring macro- and micro- (if any) ionization constants. 1H NMR spectra of aqueous solutions of eight model substrates were consequently recorded using a water suppression sequence, within large pH ranges. A set of programs was devised to treat NMR data over the entirety of pH-dependent NMR patterns, in order to smooth out errors arising in handling individual spectra. Rates of amide proton abstraction by hydroxide ions were obtained from the coalescence of methylene coupled protons and the decrease of NH bond signal intensities, allowing us to estimate and discuss peptide pKs on assuming back reprotonation at a diffusion-limited rate. Cis–trans isomerization rates in two substrates bearing a tert-Butyloxycarbonyl terminal group were put in parallel with the acidity of carbamic protons." @default.
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- W2029850670 date "2014-09-01" @default.
- W2029850670 modified "2023-10-06" @default.
- W2029850670 title "Large variations in acidity of terminal amide bonds in histamine-containing peptides as measured by proton DNMR" @default.
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- W2029850670 doi "https://doi.org/10.1016/j.tet.2014.07.024" @default.
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