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- W2029863591 abstract "Introduction: Myelofibrosis (MF), a Philadelphia chromosome-negative myeloproliferative neoplasm, is a life-threatening heterogeneous disorder characterized by dysregulation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling network. The clinical hallmarks of MF are progressive splenomegaly, anemia and debilitating symptoms attributable to ineffective hematopoiesis and excessive production of proinflammatory cytokines. Areas covered: This review describes the pathogenesis, clinical features and current treatment of MF, clinical data for ruxolitinib, a potent oral JAK1/JAK2 inhibitor and the only therapy approved for the treatment of MF, and agents in development for the treatment of MF. Information was derived from relevant MF articles identified in the published literature and abstracts of recent congresses. Expert opinion: Ruxolitinib reduces spleen size and alleviates MF-related symptoms, thereby improving quality of life. Ruxolitinib may increase the risk of anemia and thrombocytopenia and does not appear to reverse bone marrow fibrosis. Studies are exploring ruxolitinib dosing strategies for patients with low platelet counts and combination therapies. Several other JAK inhibitors and other agents (i.e., immunomodulators, antifibrotic agents, anti-anemia agents, mammalian target of rapamycin [mTOR] inhibitors, epigenetic modifiers, pegylated interferon-α2a) to treat various aspects of MF (i.e., to improve blood counts or forestall marrow fibrosis) are in early clinical development." @default.
- W2029863591 created "2016-06-24" @default.
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- W2029863591 date "2012-11-28" @default.
- W2029863591 modified "2023-09-25" @default.
- W2029863591 title "Emerging drugs for myelofibrosis" @default.
- W2029863591 cites W135049235 @default.
- W2029863591 cites W1545484310 @default.
- W2029863591 cites W1546432466 @default.
- W2029863591 cites W1966357810 @default.
- W2029863591 cites W1970101456 @default.
- W2029863591 cites W1971888832 @default.
- W2029863591 cites W1973160387 @default.
- W2029863591 cites W1973587793 @default.
- W2029863591 cites W1977686680 @default.
- W2029863591 cites W1979293726 @default.
- W2029863591 cites W1985809519 @default.
- W2029863591 cites W1993934088 @default.
- W2029863591 cites W1995981641 @default.
- W2029863591 cites W2008799537 @default.
- W2029863591 cites W2009082613 @default.
- W2029863591 cites W2009954157 @default.
- W2029863591 cites W2010293026 @default.
- W2029863591 cites W2012828222 @default.
- W2029863591 cites W2017073234 @default.
- W2029863591 cites W2020533741 @default.
- W2029863591 cites W2024706907 @default.
- W2029863591 cites W2025109100 @default.
- W2029863591 cites W2028803880 @default.
- W2029863591 cites W2028961479 @default.
- W2029863591 cites W2029548336 @default.
- W2029863591 cites W2049965335 @default.
- W2029863591 cites W2061377922 @default.
- W2029863591 cites W2069036374 @default.
- W2029863591 cites W2079645940 @default.
- W2029863591 cites W2080024052 @default.
- W2029863591 cites W2080503990 @default.
- W2029863591 cites W2081259800 @default.
- W2029863591 cites W2087327268 @default.
- W2029863591 cites W2088263025 @default.
- W2029863591 cites W2093724620 @default.
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- W2029863591 cites W2097692898 @default.
- W2029863591 cites W2099264304 @default.
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- W2029863591 cites W2105496815 @default.
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- W2029863591 doi "https://doi.org/10.1517/14728214.2012.748748" @default.
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