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- W2029873326 abstract "The drug adsorption and release characteristics of porous starches produced through hot air drying, spray drying, and vacuum freeze drying were investigated using ciprofloxacin as model drug. A UV/visible spectrophotometer, Fourier-transform infrared spectrometer, differential scanning calorimeter, and X-ray diffractometer were used to determine the drug adsorption/release, drug/starch interaction, glass transition, and crystallinity of porous starch samples. The amount of ciprofloxacin adsorbed in three different porous starches was 5.58%, 8.91%, and 11.43%, respectively. The ciprofloxacin-loaded porous starches had glass-transition-related endothermic peaks between 55°C and 65°C and melting-related endothermic peaks between 120°C and 150°C. Up to 75% of the loaded ciprofloxacin was released from the freeze-dried sample within 30 hrs. The freeze-dried porous starch also showed higher ciprofloxacin loading rate, higher glass transition temperature, and higher ciprofloxacin release rate. A two-phase dynamic drug release model was found to satisfactorily fit the release kinetics of ciprofloxacin (R2 > 0.995)." @default.
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- W2029873326 date "2013-10-26" @default.
- W2029873326 modified "2023-10-03" @default.
- W2029873326 title "The Adsorption and Release Characteristics of CPFX in Porous Starch Produced Through Different Drying Methods" @default.
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- W2029873326 doi "https://doi.org/10.1080/07373937.2013.815627" @default.
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