Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029873418> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2029873418 endingPage "S111" @default.
- W2029873418 startingPage "S101" @default.
- W2029873418 abstract "Abstract The aim of the present work is to use experimental design to screen and optimize experimental variables for developing a spectrophotometric method for determining cefixime trihydrate content using ninhydrin as a derivatizing reagent. The method is based on the reaction of the amino group of cefixime with ninhydrin in an alkaline medium to form a yellow-colored derivative ( λ max 436 nm). A two-level full factorial design was utilized to screen the effect of ninhydrin reagent concentration (X 1 ), volume of ninhydrin reagent (X 2 ), heating temperature (X 3 ) and heating time (X 4 ) on the formation of the cefixime–ninhydrin complex Y (absorbance). One way ANOVA and Pareto ranking analyses have shown that the ninhydrin reagent concentration (X 1 ), volume of ninhydrin reagent (X 2 ) and heating temperature (X 3 ) were statistically significant factors ( P 1 ) of 0.2% w/v, volume of ninhydrin reagent (X 2 ) of 1 mL and heating temperature (X 3 ) of 80 °C. The proposed method was validated according to the ICH Q2 (R1) method validation guidelines. The results of the present study have clearly shown that an experimental design concept may be effectively applied to the optimization of a spectrophotometric method for estimating the cefixime trihydrate content in bulk and pharmaceutical formulation with the least number of experimental runs possible." @default.
- W2029873418 created "2016-06-24" @default.
- W2029873418 creator A5013037600 @default.
- W2029873418 creator A5050815167 @default.
- W2029873418 date "2017-01-01" @default.
- W2029873418 modified "2023-10-02" @default.
- W2029873418 title "An experimental design approach for optimization of spectrophotometric method for estimation of cefixime trihydrate using ninhydrin as derivatizing reagent in bulk and pharmaceutical formulation" @default.
- W2029873418 cites W185647057 @default.
- W2029873418 cites W1965258535 @default.
- W2029873418 cites W1979420434 @default.
- W2029873418 cites W2004906986 @default.
- W2029873418 cites W2036942167 @default.
- W2029873418 cites W2066947166 @default.
- W2029873418 cites W2068606978 @default.
- W2029873418 cites W2080617411 @default.
- W2029873418 cites W2081743730 @default.
- W2029873418 cites W2088376206 @default.
- W2029873418 cites W2122685286 @default.
- W2029873418 cites W2144095006 @default.
- W2029873418 cites W2155129959 @default.
- W2029873418 cites W24553968 @default.
- W2029873418 doi "https://doi.org/10.1016/j.jscs.2013.11.001" @default.
- W2029873418 hasPublicationYear "2017" @default.
- W2029873418 type Work @default.
- W2029873418 sameAs 2029873418 @default.
- W2029873418 citedByCount "25" @default.
- W2029873418 countsByYear W20298734182014 @default.
- W2029873418 countsByYear W20298734182015 @default.
- W2029873418 countsByYear W20298734182016 @default.
- W2029873418 countsByYear W20298734182017 @default.
- W2029873418 countsByYear W20298734182018 @default.
- W2029873418 countsByYear W20298734182019 @default.
- W2029873418 countsByYear W20298734182020 @default.
- W2029873418 countsByYear W20298734182022 @default.
- W2029873418 countsByYear W20298734182023 @default.
- W2029873418 crossrefType "journal-article" @default.
- W2029873418 hasAuthorship W2029873418A5013037600 @default.
- W2029873418 hasAuthorship W2029873418A5050815167 @default.
- W2029873418 hasBestOaLocation W20298734181 @default.
- W2029873418 hasConcept C178790620 @default.
- W2029873418 hasConcept C185592680 @default.
- W2029873418 hasConcept C2778243283 @default.
- W2029873418 hasConcept C2778944976 @default.
- W2029873418 hasConcept C40875361 @default.
- W2029873418 hasConcept C43617362 @default.
- W2029873418 hasConcept C501593827 @default.
- W2029873418 hasConcept C515207424 @default.
- W2029873418 hasConcept C55493867 @default.
- W2029873418 hasConcept C64778159 @default.
- W2029873418 hasConceptScore W2029873418C178790620 @default.
- W2029873418 hasConceptScore W2029873418C185592680 @default.
- W2029873418 hasConceptScore W2029873418C2778243283 @default.
- W2029873418 hasConceptScore W2029873418C2778944976 @default.
- W2029873418 hasConceptScore W2029873418C40875361 @default.
- W2029873418 hasConceptScore W2029873418C43617362 @default.
- W2029873418 hasConceptScore W2029873418C501593827 @default.
- W2029873418 hasConceptScore W2029873418C515207424 @default.
- W2029873418 hasConceptScore W2029873418C55493867 @default.
- W2029873418 hasConceptScore W2029873418C64778159 @default.
- W2029873418 hasLocation W20298734181 @default.
- W2029873418 hasLocation W20298734182 @default.
- W2029873418 hasOpenAccess W2029873418 @default.
- W2029873418 hasPrimaryLocation W20298734181 @default.
- W2029873418 hasRelatedWork W1997472535 @default.
- W2029873418 hasRelatedWork W2008664189 @default.
- W2029873418 hasRelatedWork W2076297049 @default.
- W2029873418 hasRelatedWork W2078323861 @default.
- W2029873418 hasRelatedWork W2089075332 @default.
- W2029873418 hasRelatedWork W2184499735 @default.
- W2029873418 hasRelatedWork W2382113066 @default.
- W2029873418 hasRelatedWork W2795448416 @default.
- W2029873418 hasRelatedWork W2952256733 @default.
- W2029873418 hasRelatedWork W4250881596 @default.
- W2029873418 hasVolume "21" @default.
- W2029873418 isParatext "false" @default.
- W2029873418 isRetracted "false" @default.
- W2029873418 magId "2029873418" @default.
- W2029873418 workType "article" @default.