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- W2029879983 abstract "Cystic fibrosis (CF) in European Caucasians is a balanced polymorphism, presumably associated with some sort of heterozygote advantage. In the 16th century, venereal syphilis was present in Europe in the general area of the CF polymorphism; it was not present in other parts of the world, and no other fatal disease had this localization. Historical and geographic considerations therefore suggest that the CF polymorphism formed as a result of protective advantage against venereal syphilis." @default.
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- W2029879983 date "1982-02-01" @default.
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- W2029879983 title "Etiogenesis of the European cystic fibrosis polymorphism: Heterozygote advantage against venereal syphilis?" @default.
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- W2029879983 doi "https://doi.org/10.1016/0306-9877(82)90102-5" @default.
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