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- W2029881607 abstract "Recent studies have demonstrated that a serpin variant, α 1 ‐antitrypsin Portland (AT‐PDX), can inhibit the mammalian convertase furin. Here, we examine the mechanism by which this inhibition takes place. We find that furin, which does not belong to the trypsin‐like serine protease family, the usual targets of serpins, forms an SDS‐heat denaturation‐resistant complex with AT‐PDX both in vitro and in vivo. AT‐PDX inhibited furin with an association rate constant ( k ass ) of 1.5×10 6 M −1 s −1 which is similar to k ass values reported for serpins with trypsin‐like enzymes. These results illustrate that AT can be modified to act essentially as a suicide inhibitor of furin, an enzyme of the subtilase superfamily of serine proteases." @default.
- W2029881607 created "2016-06-24" @default.
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- W2029881607 date "1998-04-10" @default.
- W2029881607 modified "2023-09-25" @default.
- W2029881607 title "Serpin-like properties of α1-antitrypsin Portland towards furin convertase" @default.
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- W2029881607 doi "https://doi.org/10.1016/s0014-5793(98)00307-x" @default.
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