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- W2029885310 abstract "Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4+CD8+ stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations." @default.
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- W2029885310 date "2004-12-01" @default.
- W2029885310 modified "2023-10-18" @default.
- W2029885310 title "Development of CD1d-restricted NKT?cells in the mouse thymus" @default.
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- W2029885310 doi "https://doi.org/10.1002/eji.200425546" @default.
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