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- W2029892293 abstract "Copyright: © 2014 Lushchak VI. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Two models of dose-response relationships between dose, concentration or intensity of any effector and response of living organisms are commonly applied in biology and pharmacology [18]. In the simplest first linear model, the registered parameter shows a linear increase with increase of dose, concentration, or intensity of the effector (Figure 1A) and in some cases this linear model is also called linear non-threshold model [9]. The latter is important in order to discriminate it from the second widely applied “threshold model” when the response cannot be linearly extrapolated to “zero” level of the effector (Figure 1B). In both cases (Figure 1A and 1B), the a-angles can vary widely and depend on many factors including the model type, specific conditions used and the properties of effectors as well as do the distance “a” in Figure 1B. The latter is called the “lag phase” and may reflect the operation of defense mechanisms that prevent an immediate response by organisms. Biological and pharmacological effects depend on the cumulative effects of single acts of interaction between the effector and the biological subject." @default.
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- W2029892293 date "2014-01-01" @default.
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- W2029892293 title "Hormesis in Biology and Pharmacology" @default.
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- W2029892293 doi "https://doi.org/10.4172/2167-0501.1000e149" @default.
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