FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029892337> ?p ?o ?g. }

• W2029892337 endingPage "1153" @default.
• W2029892337 startingPage "1148" @default.
• W2029892337 abstract "The present study was designed to reexamine the muscarinic acetylcholine receptor subtype mediating carbachol-induced contraction of human urinary bladder and to investigate the underlying signal transduction. Based upon the nonselective tolterodine, the highly M₂-selective (<i>R</i>)-4-{2-[3-(4-methoxy-benzoylamino)-benzyl]-piperidin-1-ylmethyl}piperidine-1-carboxylic acid amide (Ro-320-6206), and the highly M₃-selective darifenacin and 3-(1-carbamoyl-1,1-diphenylmethyl)-1-(4-methoxyphenylethyl)pyrrolidine (APP), contraction occurs via M₃ receptors. The phospholipase C inhibitor 1-(6-[([17β]-3-methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl)-1H-pyrrole-2,5-dione (U 73,122) (1-10 μM) did not significantly affect carbachol-stimulated bladder contraction. The phospholipase D inhibitor butan-1-ol relative to its negative control butan-2-ol (0.3% each) caused small but detectable inhibition of carbachol-induced bladder contraction. The Ca²⁺ entry blocker nifedipine (10-100 nM) strongly inhibited carbachol-induced bladder contraction. In contrast, 1-[β-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1<i>H</i>-imidazole HCl (SK&F 96,365) (1-10 μM), an inhibitor of store-operated Ca²⁺ channels, caused little inhibition. The protein kinase C inhibitor bisindolylmaleimide I (1-10 μM) did not significantly affected carbachol-induced bladder contraction. In contrast, <i>trans</i>-4-[(1<i>R</i>)-1-aminoethyl]-<i>N</i>-4-pyridinylcyclohexanecarboxamide (Y 27,632) (1-10 μM), an inhibitor of rho-associated kinases, concentration dependently and effectively attenuated the carbachol responses. We conclude that carbachol-induced contraction of human urinary bladder via M₃ receptors largely depends on Ca²⁺ entry through nifedipine-sensitive channels and activation of a rho kinase, whereas phospholipase D and store-operated Ca²⁺ channels contribute only in a minor way. Surprisingly, phospholipase C or protein kinase C do not seem to be involved to a relevant extent." @default.
• W2029892337 created "2016-06-24" @default.
• W2029892337 creator A5019298885 @default.
• W2029892337 creator A5040869371 @default.
• W2029892337 creator A5060991124 @default.
• W2029892337 creator A5080696199 @default.
• W2029892337 date "2004-02-09" @default.
• W2029892337 modified "2023-09-26" @default.
• W2029892337 title "Signal Transduction Underlying Carbachol-Induced Contraction of Human Urinary Bladder" @default.
• W2029892337 cites W1745534060 @default.
• W2029892337 cites W1967023268 @default.
• W2029892337 cites W1973948158 @default.
• W2029892337 cites W1981213058 @default.
• W2029892337 cites W1983621806 @default.
• W2029892337 cites W1988216302 @default.
• W2029892337 cites W1989235608 @default.
• W2029892337 cites W1989309123 @default.
• W2029892337 cites W1991693093 @default.
• W2029892337 cites W2004181897 @default.
• W2029892337 cites W2010470645 @default.
• W2029892337 cites W2022805127 @default.
• W2029892337 cites W2029272167 @default.
• W2029892337 cites W2033939140 @default.
• W2029892337 cites W2037015060 @default.
• W2029892337 cites W2046495236 @default.
• W2029892337 cites W2048544621 @default.
• W2029892337 cites W2057823938 @default.
• W2029892337 cites W2072859373 @default.
• W2029892337 cites W2077298757 @default.
• W2029892337 cites W2081690761 @default.
• W2029892337 cites W2084079850 @default.
• W2029892337 cites W2091111772 @default.
• W2029892337 cites W2094396426 @default.
• W2029892337 cites W2101885175 @default.
• W2029892337 cites W2113550171 @default.
• W2029892337 cites W2124540551 @default.
• W2029892337 cites W2140608625 @default.
• W2029892337 cites W2148321505 @default.
• W2029892337 cites W2415733620 @default.
• W2029892337 doi "https://doi.org/10.1124/jpet.103.063735" @default.
• W2029892337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14769832" @default.
• W2029892337 hasPublicationYear "2004" @default.
• W2029892337 type Work @default.
• W2029892337 sameAs 2029892337 @default.
• W2029892337 citedByCount "152" @default.
• W2029892337 countsByYear W20298923372012 @default.
• W2029892337 countsByYear W20298923372013 @default.
• W2029892337 countsByYear W20298923372014 @default.
• W2029892337 countsByYear W20298923372015 @default.
• W2029892337 countsByYear W20298923372016 @default.
• W2029892337 countsByYear W20298923372018 @default.
• W2029892337 countsByYear W20298923372019 @default.
• W2029892337 countsByYear W20298923372020 @default.
• W2029892337 countsByYear W20298923372021 @default.
• W2029892337 countsByYear W20298923372023 @default.
• W2029892337 crossrefType "journal-article" @default.
• W2029892337 hasAuthorship W2029892337A5019298885 @default.
• W2029892337 hasAuthorship W2029892337A5040869371 @default.
• W2029892337 hasAuthorship W2029892337A5060991124 @default.
• W2029892337 hasAuthorship W2029892337A5080696199 @default.
• W2029892337 hasConcept C126322002 @default.
• W2029892337 hasConcept C134018914 @default.
• W2029892337 hasConcept C163415756 @default.
• W2029892337 hasConcept C170493617 @default.
• W2029892337 hasConcept C185592680 @default.
• W2029892337 hasConcept C2778597717 @default.
• W2029892337 hasConcept C2778988552 @default.
• W2029892337 hasConcept C33789571 @default.
• W2029892337 hasConcept C55493867 @default.
• W2029892337 hasConcept C71924100 @default.
• W2029892337 hasConcept C86803240 @default.
• W2029892337 hasConceptScore W2029892337C126322002 @default.
• W2029892337 hasConceptScore W2029892337C134018914 @default.
• W2029892337 hasConceptScore W2029892337C163415756 @default.
• W2029892337 hasConceptScore W2029892337C170493617 @default.
• W2029892337 hasConceptScore W2029892337C185592680 @default.
• W2029892337 hasConceptScore W2029892337C2778597717 @default.
• W2029892337 hasConceptScore W2029892337C2778988552 @default.
• W2029892337 hasConceptScore W2029892337C33789571 @default.
• W2029892337 hasConceptScore W2029892337C55493867 @default.
• W2029892337 hasConceptScore W2029892337C71924100 @default.
• W2029892337 hasConceptScore W2029892337C86803240 @default.
• W2029892337 hasIssue "3" @default.
• W2029892337 hasLocation W20298923371 @default.
• W2029892337 hasLocation W20298923372 @default.
• W2029892337 hasOpenAccess W2029892337 @default.
• W2029892337 hasPrimaryLocation W20298923371 @default.
• W2029892337 hasRelatedWork W1901275661 @default.
• W2029892337 hasRelatedWork W1986343589 @default.
• W2029892337 hasRelatedWork W2011899523 @default.
• W2029892337 hasRelatedWork W2022685867 @default.
• W2029892337 hasRelatedWork W2034583712 @default.
• W2029892337 hasRelatedWork W2040046061 @default.
• W2029892337 hasRelatedWork W2050559793 @default.
• W2029892337 hasRelatedWork W2063619316 @default.
• W2029892337 hasRelatedWork W2094064741 @default.
• W2029892337 hasRelatedWork W2169225653 @default.
• W2029892337 hasVolume "309" @default.

• next