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• W2029897116 abstract "Numerous studies have demonstrated that the brain is one of the target organs in acute or chronic titanium dioxide (TiO2) nanoparticles (NPs) toxicity, and oxidative stress plays an important role in this process. However, whether brain oxidative injury responds to TiO2 NPs by activating the P38-nuclear factor-E2-related factor-2 (Nrf-2) pathway is not fully understood. The present study aimed to examine activation of the P38-Nrf-2 signaling pathway associated with oxidative stress in the mouse brain induced by intranasal administration of TiO2 NPs for 90 consecutive days. Our findings indicate that TiO2 NPs caused overproliferation of spongiocytes and hemorrhage in the mouse brain. Furthermore, TiO2 NPs significantly activated p38, c-Jun N-terminal kinase, nuclear factor kappa B, Nrf-2 and heme oxygenase-1 expression in the brain, which in turn, led to increased production of reactive oxygen species, as well as lipid, protein and DNA peroxidation. These findings suggest that TiO2 NPs-induced oxidative damage in the mouse brain may occur via the p38-Nrf-2 signaling pathway. Therefore, application of TiO2 NPs in the environment should be performed with caution." @default.
• W2029897116 created "2016-06-24" @default.
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• W2029897116 date "2013-08-01" @default.
• W2029897116 modified "2023-10-16" @default.
• W2029897116 title "Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice" @default.
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• W2029897116 cites W1971465028 @default.
• W2029897116 cites W1973081785 @default.
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• W2029897116 cites W1979093868 @default.
• W2029897116 cites W1980754997 @default.
• W2029897116 cites W1987767047 @default.
• W2029897116 cites W1991005777 @default.
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• W2029897116 cites W2006311748 @default.
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• W2029897116 doi "https://doi.org/10.1016/j.chemosphere.2013.01.094" @default.
• W2029897116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23466083" @default.
• W2029897116 hasPublicationYear "2013" @default.
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