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• W2029897357 abstract "In this paper we evaluated the effects of the interaction of TiO2 nanoparticles (nano-TiO2) with bisphenol A (BPA) on their physicochemical properties and in vitro toxicity in human embryo L-02 hepatocytes. Different concentrations of BPA (0, 0.1, 1, 10 μmol/L) and nano-TiO2 (0, 0.1, 1, 10 mg/L) were mixed to analyze the size distribution, zeta potential, adsorption capacity and uptake of nano-TiO2, and the toxicity of nano-TiO2 and BPA in L-02 cells. The addition of BPA to nano-TiO2 dispersions increased the aggregation level and zeta potential of nano-TiO2 in all media. Nano-TiO2 had a similar adsorption capacity in different media, although a higher aggregation level was observed in cell culture medium. Nano-TiO2, with or without BPA, could enter L-02 cells after 24 h exposure. Nano-TiO2 alone did not induce significant DNA and chromosome damage, but the mixture of nano-TiO2 and BPA increased toxicity via increasing oxidative stress, DNA double strand breaks and micronuclei formation. The aggregated nano-TiO2 can enrich BPA effectively. The BPA-bound nano-TiO2 are proven to be uptaken into nuclei of exposed cells, which may increase intracellular BPA and nano-TiO2 levels and thus lead to synergistic toxicity. However only small synergic effects were observed at the concentrations of BPA and nano-TiO2 used in this study." @default.
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• W2029897357 date "2012-01-01" @default.
• W2029897357 modified "2023-09-25" @default.
• W2029897357 title "Effects of the interaction of TiO2 nanoparticles with bisphenol A on their physicochemical properties and in vitro toxicity" @default.
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• W2029897357 doi "https://doi.org/10.1016/j.jhazmat.2011.11.040" @default.
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