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• W2029907535 abstract "To examine the effects of basic fibroblast growth factor (bFGF) on the inhibition of α-smooth muscle actin (α-SMA) expression in dermal fibroblasts, we have established two dermal myofibroblastic cell lines positive for α-SMA (rat myofibroblasts [RMF] and rat myofibroblast-like [RMFL] cells) and one fibroblastic cell line negative for α-SMA (rat fibroblasts cells) as a model of fibroblast differentiation. In contrast to the increased expression of α-SMA in RMF and RMFL cells, irrespective of transforming growth factor-β1 treatment, bFGF induced a decrease in α-SMA expression in the myofibroblastic cells and the reduced expression patterns of α-SMA differed between cells, as demonstrated by Western blot and reverse transcription polymerase chain reaction analyses. Along with the inhibition of α-SMA expression by bFGF, the RMF and RMFL cells also showed different activated expression of extracellular signal-regulated kinase 1/2, suggesting the involvement of extracellular signal-regulated kinase 1/2 activation in the down-regulation of α-SMA expression in myofibroblasts. Furthermore, an in vivo study demonstrated that bFGF administration markedly decreases the area that is positive for α-SMA expression in the treated wounds after day 18. In contrast, bFGF administration significantly increased the number of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) staining and α-SMA-positive cells at days 10 and 14, and reduced the double-positive cells rapidly after day 18. Collectively, the current investigation identified bFGF as a potent stimulator for the reduction of the myofibroblastic area in vivo, presumably because of its effects on the down-regulation of α-SMA expression as well as rapid induction of apoptosis in myofibroblasts." @default.
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• W2029907535 date "2009-07-01" @default.
• W2029907535 modified "2023-09-28" @default.
• W2029907535 title "Basic fibroblast growth factor induces down-regulation of α-smooth muscle actin and reduction of myofibroblast areas in open skin wounds" @default.
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• W2029907535 doi "https://doi.org/10.1111/j.1524-475x.2009.00511.x" @default.
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