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- W2029908443 abstract "Complexes [Bi(PzAm4DH)Cl2] (1), [Bi(PzAm4M)Cl2] (2), [Bi(PzAm4E)Cl2] (3), [Bi(PzAm4Cy)Cl2]⋅3H2O (4) and [Bi(PzAm4Ph)Cl2] (5) were prepared with 2-pyrazineformamide- (HPzAm4DH, L1), N(4)-methyl-2-pyrazineformamide- (HPzAm4M, L2), N(4)-ethyl-2-pyrazineformamide- (HPzAm4E, L3), N(4)-cyclohexyl-2-pyrazineformamide (HPzAm4Cy, L4) and N(4)-phenyl-2-pyrazineformamide (HPzAm4Ph, L5) thiosemicarbazones. L4 crystallized from methanol in monoclinic crystal system. All compounds were assayed for their cytotoxicity against SF-295 (glioblastoma multiforme) and HCT-116 (colon adenocarcinoma) human tumor cell lines and Mycobacterium tuberculosis H37Rv ATCC 27294 strain. Complexes 1–5 proved to have poor activity against the tumor cells at 5 μg/mL, whereas for complexes 4 and 5, coordination to Bi(III) was an effective strategy to increase the antimycobacterial activity of the thiosemicarbazones L4 and L5." @default.
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- W2029908443 date "2008-01-01" @default.
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- W2029908443 title "Varón de 33 años con hemorragia digestiva alta y dolor epigástrico" @default.
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- W2029908443 doi "https://doi.org/10.1157/13115009" @default.
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