FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029912899> ?p ?o ?g. }

• W2029912899 endingPage "764" @default.
• W2029912899 startingPage "749" @default.
• W2029912899 abstract "Adenosinergic and muscarinic agents have been shown to attenuate the catecholamine-induced augmentation of both protein phosphorylation and contractile state in perfused hearts. The attenuation by phenylisopropyl-adenosine (PIA) and carbamylcholine chloride (CARB) of the isoproterenol (ISO)-induced incorporation of 32P into protein substrates was examined in isolated rat ventricular myocytes. 32P-labelled myocytes exposed to ISO (0.1 μm, 30 s) demonstrated up to an eight-fold increase of 32P incorporation into three protein substrates (155, 31, 6 kD). When myocytes were pre-incubated with either PIA or CARB for 60 s, the ISO-induced 32P incorporation in the 31 kD and the 155 kD substrates was attenuated 37% and 25%, respectively by 1 μm PIA and only 23% and 11%, by 10 μm PIA. A concentration of 1 μm CARB produced a 24% and 17% reduction in these same substrates while 10 μm CARB produced a 44% and 50% reduction. The effects of ISO were antagonized by 10 μm propanolol. The inhibitory effects of PIA were antagonized by the theophylline, sulfophenyltheophylline and dipropylcyclopentylxanthine, whereas atropine antagonized the inhibitory effects of CARB. The 32P incorporation elicited by 1 μm forskolin was reduced more by CARB than PIA. Additionally, while PIA and CARB reduced the ISO-induced increase in cAMP-dependent protein kinase (PKA) activity by 48% and 41% respectively, only CARB attenuated the ISO-elicited increase in cAMP levels, attenuating this response by 58%. The results indicate that PIA was less effective in attenuating ISO-induced 32P incorporation at higher concentrations than at lower concentrations. Moreover, this compound was less potent than CARB at attenuating the effects of ISO. It is conceivable that this difference could be related to activation of stimulatory adenosine receptors (A2) and/or a greater density of muscarinic receptors including multiple inhibitory muscarinic pathways." @default.
• W2029912899 created "2016-06-24" @default.
• W2029912899 creator A5018831207 @default.
• W2029912899 creator A5026543879 @default.
• W2029912899 creator A5062041061 @default.
• W2029912899 date "1991-06-01" @default.
• W2029912899 modified "2023-10-02" @default.
• W2029912899 title "Adenosine and acetylcholine reduce isoproterenol-induced protein phosphorylation of rat myocytes" @default.
• W2029912899 cites W1501063278 @default.
• W2029912899 cites W1502852420 @default.
• W2029912899 cites W1520717074 @default.
• W2029912899 cites W1531504909 @default.
• W2029912899 cites W1595835172 @default.
• W2029912899 cites W1643779836 @default.
• W2029912899 cites W1819240213 @default.
• W2029912899 cites W1851251799 @default.
• W2029912899 cites W1871055742 @default.
• W2029912899 cites W1939287950 @default.
• W2029912899 cites W1969929624 @default.
• W2029912899 cites W1981132317 @default.
• W2029912899 cites W1986211781 @default.
• W2029912899 cites W1995645167 @default.
• W2029912899 cites W2002828226 @default.
• W2029912899 cites W2003815319 @default.
• W2029912899 cites W2020093115 @default.
• W2029912899 cites W2021282204 @default.
• W2029912899 cites W2021547301 @default.
• W2029912899 cites W2040062675 @default.
• W2029912899 cites W2041165688 @default.
• W2029912899 cites W2044539288 @default.
• W2029912899 cites W2047821835 @default.
• W2029912899 cites W2054042510 @default.
• W2029912899 cites W2067795336 @default.
• W2029912899 cites W2079482882 @default.
• W2029912899 cites W2100837269 @default.
• W2029912899 cites W2110983953 @default.
• W2029912899 cites W2121387975 @default.
• W2029912899 cites W2142578226 @default.
• W2029912899 cites W2154791937 @default.
• W2029912899 cites W2166076256 @default.
• W2029912899 cites W2236147986 @default.
• W2029912899 cites W2251920431 @default.
• W2029912899 cites W2401185470 @default.
• W2029912899 cites W2409072338 @default.
• W2029912899 cites W2412446255 @default.
• W2029912899 cites W2416637208 @default.
• W2029912899 cites W2460243333 @default.
• W2029912899 cites W371029077 @default.
• W2029912899 cites W50645026 @default.
• W2029912899 doi "https://doi.org/10.1016/0022-2828(91)90984-t" @default.
• W2029912899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1658344" @default.
• W2029912899 hasPublicationYear "1991" @default.
• W2029912899 type Work @default.
• W2029912899 sameAs 2029912899 @default.
• W2029912899 citedByCount "39" @default.
• W2029912899 countsByYear W20299128992016 @default.
• W2029912899 countsByYear W20299128992021 @default.
• W2029912899 crossrefType "journal-article" @default.
• W2029912899 hasAuthorship W2029912899A5018831207 @default.
• W2029912899 hasAuthorship W2029912899A5026543879 @default.
• W2029912899 hasAuthorship W2029912899A5062041061 @default.
• W2029912899 hasConcept C11960822 @default.
• W2029912899 hasConcept C126322002 @default.
• W2029912899 hasConcept C134018914 @default.
• W2029912899 hasConcept C170493617 @default.
• W2029912899 hasConcept C185592680 @default.
• W2029912899 hasConcept C195794163 @default.
• W2029912899 hasConcept C202751555 @default.
• W2029912899 hasConcept C207200792 @default.
• W2029912899 hasConcept C24998067 @default.
• W2029912899 hasConcept C2775859210 @default.
• W2029912899 hasConcept C2775910092 @default.
• W2029912899 hasConcept C2776090920 @default.
• W2029912899 hasConcept C2776991684 @default.
• W2029912899 hasConcept C2779276759 @default.
• W2029912899 hasConcept C33789571 @default.
• W2029912899 hasConcept C55493867 @default.
• W2029912899 hasConcept C71924100 @default.
• W2029912899 hasConcept C86803240 @default.
• W2029912899 hasConcept C97029542 @default.
• W2029912899 hasConceptScore W2029912899C11960822 @default.
• W2029912899 hasConceptScore W2029912899C126322002 @default.
• W2029912899 hasConceptScore W2029912899C134018914 @default.
• W2029912899 hasConceptScore W2029912899C170493617 @default.
• W2029912899 hasConceptScore W2029912899C185592680 @default.
• W2029912899 hasConceptScore W2029912899C195794163 @default.
• W2029912899 hasConceptScore W2029912899C202751555 @default.
• W2029912899 hasConceptScore W2029912899C207200792 @default.
• W2029912899 hasConceptScore W2029912899C24998067 @default.
• W2029912899 hasConceptScore W2029912899C2775859210 @default.
• W2029912899 hasConceptScore W2029912899C2775910092 @default.
• W2029912899 hasConceptScore W2029912899C2776090920 @default.
• W2029912899 hasConceptScore W2029912899C2776991684 @default.
• W2029912899 hasConceptScore W2029912899C2779276759 @default.
• W2029912899 hasConceptScore W2029912899C33789571 @default.
• W2029912899 hasConceptScore W2029912899C55493867 @default.
• W2029912899 hasConceptScore W2029912899C71924100 @default.
• W2029912899 hasConceptScore W2029912899C86803240 @default.

• next