Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029919762> ?p ?o ?g. }
- W2029919762 endingPage "3991" @default.
- W2029919762 startingPage "3981" @default.
- W2029919762 abstract "Orientation selectivity (OS) of visual cortical neurons is progressively sharpened during development. However, synaptic circuit mechanisms underlying the OS sharpening remain unclear. In the current study, in vivo whole-cell voltage-clamp recordings from layer 4 excitatory neurons in the developing mouse primary visual cortex revealed changes of orientation tuning profiles of their excitatory and inhibitory inputs during a post-eye-opening period when OS of their spiking responses becomes sharpened. In addition to a parallel strengthening of excitation and inhibition during this developmental period, the orientation tuning of excitatory inputs keeps relatively constant, whereas the tuning of inhibitory inputs is broadened, and becomes significantly broader than that of excitatory inputs. Neuron modeling and dynamic-clamp recording demonstrated that this developmental broadening of the inhibitory tuning is sufficient for sharpening OS. Depriving visual experience by dark rearing impedes the normal developmental strengthening of excitation, but a similar broadening of inhibitory tuning, likely caused by a nonselective strengthening of inhibitory connections, results in the apparently normal OS sharpening in excitatory neurons. Our results thus provide the first demonstration that an inhibitory synaptic mechanism can primarily mediate the functional refinement of cortical neurons." @default.
- W2029919762 created "2016-06-24" @default.
- W2029919762 creator A5002471656 @default.
- W2029919762 creator A5009261297 @default.
- W2029919762 creator A5060541627 @default.
- W2029919762 creator A5070438434 @default.
- W2029919762 creator A5089811221 @default.
- W2029919762 date "2012-03-21" @default.
- W2029919762 modified "2023-10-13" @default.
- W2029919762 title "Broadening of Cortical Inhibition Mediates Developmental Sharpening of Orientation Selectivity" @default.
- W2029919762 cites W1487635614 @default.
- W2029919762 cites W1501153304 @default.
- W2029919762 cites W1757333299 @default.
- W2029919762 cites W1860783201 @default.
- W2029919762 cites W1867287134 @default.
- W2029919762 cites W1930030592 @default.
- W2029919762 cites W1967721763 @default.
- W2029919762 cites W1978112296 @default.
- W2029919762 cites W1982195338 @default.
- W2029919762 cites W1992828185 @default.
- W2029919762 cites W1992927229 @default.
- W2029919762 cites W1996168091 @default.
- W2029919762 cites W1997175896 @default.
- W2029919762 cites W1997375364 @default.
- W2029919762 cites W2001716460 @default.
- W2029919762 cites W2007201962 @default.
- W2029919762 cites W2008240154 @default.
- W2029919762 cites W2014906957 @default.
- W2029919762 cites W2015147756 @default.
- W2029919762 cites W2015701831 @default.
- W2029919762 cites W2032747975 @default.
- W2029919762 cites W2035251383 @default.
- W2029919762 cites W2036065817 @default.
- W2029919762 cites W2038605015 @default.
- W2029919762 cites W2046426203 @default.
- W2029919762 cites W2047648722 @default.
- W2029919762 cites W2048962026 @default.
- W2029919762 cites W2051526952 @default.
- W2029919762 cites W2053503450 @default.
- W2029919762 cites W2057326122 @default.
- W2029919762 cites W2064568361 @default.
- W2029919762 cites W2066101989 @default.
- W2029919762 cites W2072378554 @default.
- W2029919762 cites W2085718223 @default.
- W2029919762 cites W2086871516 @default.
- W2029919762 cites W2090286902 @default.
- W2029919762 cites W2093807483 @default.
- W2029919762 cites W2096006516 @default.
- W2029919762 cites W2099525751 @default.
- W2029919762 cites W2105071895 @default.
- W2029919762 cites W2106700142 @default.
- W2029919762 cites W2112927882 @default.
- W2029919762 cites W2113055360 @default.
- W2029919762 cites W2115163676 @default.
- W2029919762 cites W2115656514 @default.
- W2029919762 cites W2116360511 @default.
- W2029919762 cites W2117940227 @default.
- W2029919762 cites W2118323461 @default.
- W2029919762 cites W2124909604 @default.
- W2029919762 cites W2126020484 @default.
- W2029919762 cites W2130954011 @default.
- W2029919762 cites W2137413309 @default.
- W2029919762 cites W2141091281 @default.
- W2029919762 cites W2143886954 @default.
- W2029919762 cites W2146726961 @default.
- W2029919762 cites W2152754043 @default.
- W2029919762 cites W2156780983 @default.
- W2029919762 cites W2159749299 @default.
- W2029919762 cites W2162860740 @default.
- W2029919762 cites W2409539389 @default.
- W2029919762 cites W78502128 @default.
- W2029919762 cites W94194614 @default.
- W2029919762 doi "https://doi.org/10.1523/jneurosci.5514-11.2012" @default.
- W2029919762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3372461" @default.
- W2029919762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22442065" @default.
- W2029919762 hasPublicationYear "2012" @default.
- W2029919762 type Work @default.
- W2029919762 sameAs 2029919762 @default.
- W2029919762 citedByCount "53" @default.
- W2029919762 countsByYear W20299197622012 @default.
- W2029919762 countsByYear W20299197622013 @default.
- W2029919762 countsByYear W20299197622014 @default.
- W2029919762 countsByYear W20299197622015 @default.
- W2029919762 countsByYear W20299197622016 @default.
- W2029919762 countsByYear W20299197622017 @default.
- W2029919762 countsByYear W20299197622018 @default.
- W2029919762 countsByYear W20299197622019 @default.
- W2029919762 countsByYear W20299197622020 @default.
- W2029919762 countsByYear W20299197622021 @default.
- W2029919762 countsByYear W20299197622022 @default.
- W2029919762 crossrefType "journal-article" @default.
- W2029919762 hasAuthorship W2029919762A5002471656 @default.
- W2029919762 hasAuthorship W2029919762A5009261297 @default.
- W2029919762 hasAuthorship W2029919762A5060541627 @default.
- W2029919762 hasAuthorship W2029919762A5070438434 @default.
- W2029919762 hasAuthorship W2029919762A5089811221 @default.
- W2029919762 hasBestOaLocation W20299197621 @default.
- W2029919762 hasConcept C112592302 @default.