FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029921843> ?p ?o ?g. }

• W2029921843 endingPage "2245" @default.
• W2029921843 startingPage "2233" @default.
• W2029921843 abstract "Using a continuous perfusion system, synaptosomes prepared from rat brain released [3H]norepinephrine in a Ca2+-dependent manner when pulse depolarized by briefly elevating external potassium concentrations. Tetrodotoxin (10(-7) M), a sodium channel blocker, inhibited 48% of this pulsed release, and D595 (10(-5) M), a phenethylamine-type calcium channel blocker, inhibited 21%. In combination, these two specific ion channel antagonists appear to function independently of each other in an additive fashion. Addition of deltamethrin to this preparation resulted in an enhanced release of [3H]norepinephrine which occurred in a biphasic fashion. At 10(-7) M, deltamethrin produced a 42% enhancement in the first or initial peak of [3H]norepinephrine release and a 100% enhancement in the second or tailing peak. Addition of deltamethrin to tetrodotoxin-pretreated synaptosomes resulted in a net 37% enhancement of the initial peak release and a net increase of 277% in the tailing peak. Addition of deltamethrin to D595-pretreated synaptosomes produced no significant effect on enhanced [3H]norepinephrine release from either peak. Since tetrodotoxin is a specific sodium channel blocker, deltamethrin may be enhancing [3H]norepinephrine release by increasing the uptake of Ca2 via other voltage-gated channels (e.g. calcium) or exchange mechanisms in addition to its action at voltage-gated sodium channels. To determine whether deltamethrin may also have an effect on intraterminal Ca2+ homeostasis, external Ca2+ was replaced with Ba2+ and synaptosomes were depolarized with pentylenetetrazole (PTZ). At 10(-5) M, deltamethrin produced a 66% increase in neurotransmitter release over that produced by PTZ alone. An estimated EC50 value of deltamethrin for PTZ-induced release was calculated to be 2.4 x 10(-10) M." @default.
• W2029921843 created "2016-06-24" @default.
• W2029921843 creator A5028380835 @default.
• W2029921843 creator A5052361629 @default.
• W2029921843 date "1989-07-01" @default.
• W2029921843 modified "2023-10-16" @default.
• W2029921843 title "Role of ion channels and intraterminal calcium homeostasis in the action of deltamethrin at presynaptic nerve terminals" @default.
• W2029921843 cites W1520628061 @default.
• W2029921843 cites W1553693448 @default.
• W2029921843 cites W1567125032 @default.
• W2029921843 cites W1569556111 @default.
• W2029921843 cites W1775749144 @default.
• W2029921843 cites W1967749565 @default.
• W2029921843 cites W1969795675 @default.
• W2029921843 cites W1972484458 @default.
• W2029921843 cites W1973048453 @default.
• W2029921843 cites W1975490004 @default.
• W2029921843 cites W1985364946 @default.
• W2029921843 cites W1987476658 @default.
• W2029921843 cites W1991834773 @default.
• W2029921843 cites W1992298216 @default.
• W2029921843 cites W1996749339 @default.
• W2029921843 cites W1999164562 @default.
• W2029921843 cites W2005486367 @default.
• W2029921843 cites W2007453287 @default.
• W2029921843 cites W2008486410 @default.
• W2029921843 cites W2015523218 @default.
• W2029921843 cites W2015611414 @default.
• W2029921843 cites W2016574532 @default.
• W2029921843 cites W2017663138 @default.
• W2029921843 cites W2019962936 @default.
• W2029921843 cites W2020949479 @default.
• W2029921843 cites W2034464726 @default.
• W2029921843 cites W2034692754 @default.
• W2029921843 cites W2036772453 @default.
• W2029921843 cites W2037048489 @default.
• W2029921843 cites W2037558481 @default.
• W2029921843 cites W2039550204 @default.
• W2029921843 cites W2039615051 @default.
• W2029921843 cites W2041478806 @default.
• W2029921843 cites W2044902565 @default.
• W2029921843 cites W2049907486 @default.
• W2029921843 cites W2050215995 @default.
• W2029921843 cites W2051475589 @default.
• W2029921843 cites W2053559739 @default.
• W2029921843 cites W2055170574 @default.
• W2029921843 cites W2060533392 @default.
• W2029921843 cites W2060630122 @default.
• W2029921843 cites W2061056399 @default.
• W2029921843 cites W2063065411 @default.
• W2029921843 cites W2064366559 @default.
• W2029921843 cites W2068491414 @default.
• W2029921843 cites W2069245066 @default.
• W2029921843 cites W2074913004 @default.
• W2029921843 cites W2077936658 @default.
• W2029921843 cites W2081133171 @default.
• W2029921843 cites W2081247641 @default.
• W2029921843 cites W2083462960 @default.
• W2029921843 cites W2083726414 @default.
• W2029921843 cites W2088140336 @default.
• W2029921843 cites W2090766368 @default.
• W2029921843 cites W2120174031 @default.
• W2029921843 cites W2147608198 @default.
• W2029921843 cites W2412042843 @default.
• W2029921843 doi "https://doi.org/10.1016/0006-2952(89)90460-7" @default.
• W2029921843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2546560" @default.
• W2029921843 hasPublicationYear "1989" @default.
• W2029921843 type Work @default.
• W2029921843 sameAs 2029921843 @default.
• W2029921843 citedByCount "35" @default.
• W2029921843 countsByYear W20299218432012 @default.
• W2029921843 countsByYear W20299218432015 @default.
• W2029921843 countsByYear W20299218432022 @default.
• W2029921843 crossrefType "journal-article" @default.
• W2029921843 hasAuthorship W2029921843A5028380835 @default.
• W2029921843 hasAuthorship W2029921843A5052361629 @default.
• W2029921843 hasConcept C12554922 @default.
• W2029921843 hasConcept C126322002 @default.
• W2029921843 hasConcept C134018914 @default.
• W2029921843 hasConcept C153461711 @default.
• W2029921843 hasConcept C161176658 @default.
• W2029921843 hasConcept C170493617 @default.
• W2029921843 hasConcept C178790620 @default.
• W2029921843 hasConcept C185592680 @default.
• W2029921843 hasConcept C18699975 @default.
• W2029921843 hasConcept C2776219046 @default.
• W2029921843 hasConcept C2776414672 @default.
• W2029921843 hasConcept C2776741303 @default.
• W2029921843 hasConcept C2776986425 @default.
• W2029921843 hasConcept C2777553912 @default.
• W2029921843 hasConcept C2778514916 @default.
• W2029921843 hasConcept C2778921374 @default.
• W2029921843 hasConcept C4141045 @default.
• W2029921843 hasConcept C50952357 @default.
• W2029921843 hasConcept C513476851 @default.
• W2029921843 hasConcept C519063684 @default.
• W2029921843 hasConcept C537181965 @default.
• W2029921843 hasConcept C55493867 @default.

• next