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- W2029923902 abstract "Progressive systemic scleroderma (PAA) is characterized by fibrosclerosis of the skin and numerous visceral organs. The prognosis of the disease is decisively determined by its tendency to spread and by the extent of the functional disturbances caused by the disorder. Depending on the cutaneous fibrosis pattern, various clinical forms of manifestation are distinguished, each taking a prognostically different course. As the disease progresses protractedly, different patterns of fibrosis become manifest which do not go beyond the hand or elbow region. However, if the fibrosclerosis ascends from peripheral to proximal upwards or if it develops at the trunk with a fibro-oedema and a tendency to centrifugal spreading, the course is overshadowed by functional disturbances of visceral organs. An additional assessment of the prognosis of progressive systemic scleroderma becomes possible by means of antinuclear antibodies, especially anticentromeric antibodies or scl-70 antibodies; the prognosis is further assisted by including the genes of the HLA system in the assessment." @default.
- W2029923902 created "2016-06-24" @default.
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- W2029923902 date "1996-07-01" @default.
- W2029923902 modified "2023-09-23" @default.
- W2029923902 title "Diagnostische und prognostische Parameter der Progressiven systemischen Sklerodermie" @default.
- W2029923902 doi "https://doi.org/10.1055/s-2008-1043710" @default.
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