Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029930251> ?p ?o ?g. }
- W2029930251 endingPage "160" @default.
- W2029930251 startingPage "155" @default.
- W2029930251 abstract "Abstract Many diseases with a major public health impact are the result of complex interactions between environmental factors and multiple genes. In the past decade, methods for genome analysis, in particular quantitative trait locus (QTL) analysis in animal models, were developed to identify and localize the genes responsible for multifactorial (polygenic) diseases; QTL analysis is based on experimental crosses between inbred strains with high and low genetic susceptibility. Recently the genes underlying several QTLs could be cloned successfully. Here we describe the impact of these genomic approaches in mice on our understanding of the multifactorial genetics of three gastrointestinal diseases related to metabolism (cholesterol cholelithiasis), development (gastroschisis), and colorectal cancer. The examples demonstrate how mouse models continue to be an invaluable tool in unravelling complex pathomechanisms and unlocking our understanding of human diseases." @default.
- W2029930251 created "2016-06-24" @default.
- W2029930251 creator A5013003026 @default.
- W2029930251 creator A5031672899 @default.
- W2029930251 creator A5068159662 @default.
- W2029930251 date "2003-02-01" @default.
- W2029930251 modified "2023-10-17" @default.
- W2029930251 title "Mouse models for genetic dissection of polygenic gastrointestinal diseases" @default.
- W2029930251 cites W1482218984 @default.
- W2029930251 cites W1879942467 @default.
- W2029930251 cites W1929425341 @default.
- W2029930251 cites W1964589415 @default.
- W2029930251 cites W1965933400 @default.
- W2029930251 cites W1975993620 @default.
- W2029930251 cites W1976388047 @default.
- W2029930251 cites W1979105334 @default.
- W2029930251 cites W1986290379 @default.
- W2029930251 cites W1990606472 @default.
- W2029930251 cites W1994558620 @default.
- W2029930251 cites W1997477483 @default.
- W2029930251 cites W2000130011 @default.
- W2029930251 cites W2009720062 @default.
- W2029930251 cites W2011706490 @default.
- W2029930251 cites W2016208474 @default.
- W2029930251 cites W2016734170 @default.
- W2029930251 cites W2017104522 @default.
- W2029930251 cites W2025661760 @default.
- W2029930251 cites W2026644829 @default.
- W2029930251 cites W2027189086 @default.
- W2029930251 cites W2034269086 @default.
- W2029930251 cites W2034603040 @default.
- W2029930251 cites W2038746094 @default.
- W2029930251 cites W2050321525 @default.
- W2029930251 cites W2051686420 @default.
- W2029930251 cites W2052555886 @default.
- W2029930251 cites W2055913006 @default.
- W2029930251 cites W2057026748 @default.
- W2029930251 cites W2057830803 @default.
- W2029930251 cites W2061569374 @default.
- W2029930251 cites W2070580124 @default.
- W2029930251 cites W2083673779 @default.
- W2029930251 cites W2084659900 @default.
- W2029930251 cites W2088717715 @default.
- W2029930251 cites W2092691551 @default.
- W2029930251 cites W2093187453 @default.
- W2029930251 cites W2093531978 @default.
- W2029930251 cites W2106253081 @default.
- W2029930251 cites W2112362866 @default.
- W2029930251 cites W2114417847 @default.
- W2029930251 cites W2115142210 @default.
- W2029930251 cites W2118428126 @default.
- W2029930251 cites W2124387047 @default.
- W2029930251 cites W2133827179 @default.
- W2029930251 cites W2134066661 @default.
- W2029930251 cites W2148278870 @default.
- W2029930251 cites W2160709026 @default.
- W2029930251 cites W2161565570 @default.
- W2029930251 cites W2167137787 @default.
- W2029930251 cites W2188742519 @default.
- W2029930251 cites W2336160773 @default.
- W2029930251 cites W2336169581 @default.
- W2029930251 cites W2626800913 @default.
- W2029930251 cites W31254998 @default.
- W2029930251 doi "https://doi.org/10.1046/j.1365-2362.2003.01089.x" @default.
- W2029930251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12588290" @default.
- W2029930251 hasPublicationYear "2003" @default.
- W2029930251 type Work @default.
- W2029930251 sameAs 2029930251 @default.
- W2029930251 citedByCount "14" @default.
- W2029930251 countsByYear W20299302512014 @default.
- W2029930251 countsByYear W20299302512015 @default.
- W2029930251 crossrefType "journal-article" @default.
- W2029930251 hasAuthorship W2029930251A5013003026 @default.
- W2029930251 hasAuthorship W2029930251A5031672899 @default.
- W2029930251 hasAuthorship W2029930251A5068159662 @default.
- W2029930251 hasConcept C104317684 @default.
- W2029930251 hasConcept C122735190 @default.
- W2029930251 hasConcept C141231307 @default.
- W2029930251 hasConcept C21249469 @default.
- W2029930251 hasConcept C30481170 @default.
- W2029930251 hasConcept C54355233 @default.
- W2029930251 hasConcept C60644358 @default.
- W2029930251 hasConcept C70721500 @default.
- W2029930251 hasConcept C81941488 @default.
- W2029930251 hasConcept C84597430 @default.
- W2029930251 hasConcept C86803240 @default.
- W2029930251 hasConceptScore W2029930251C104317684 @default.
- W2029930251 hasConceptScore W2029930251C122735190 @default.
- W2029930251 hasConceptScore W2029930251C141231307 @default.
- W2029930251 hasConceptScore W2029930251C21249469 @default.
- W2029930251 hasConceptScore W2029930251C30481170 @default.
- W2029930251 hasConceptScore W2029930251C54355233 @default.
- W2029930251 hasConceptScore W2029930251C60644358 @default.
- W2029930251 hasConceptScore W2029930251C70721500 @default.
- W2029930251 hasConceptScore W2029930251C81941488 @default.
- W2029930251 hasConceptScore W2029930251C84597430 @default.
- W2029930251 hasConceptScore W2029930251C86803240 @default.
- W2029930251 hasIssue "2" @default.