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- W2029931114 abstract "Although life prevalence of substance use disorders among patients with schizophrenia is close to 50%, few studies have been carried out to date to identify an integrated pharmacological treatment for this comorbidity. So far, the most promising results, that we report here, have been obtained with clozapine. To a lesser extent, quetiapine and olanzapine, both clozapine analogues, have also shown promising results. Further to these observations, the present paper critically reviews the advantages associated with clozapine, quetiapine and olanzapine, and their relevance to the treatment of addiction among schizophrenic patients. Six characteristics seem to distinguish clozapine, quetiapine and olanzapine from the firstgeneration antipsychotics: (1) acting preferentially on the reward system, these second-generation antipsychotics (mainly clozapine and quetiapine) induce almostno extrapyramidal symptoms;(2) quickly dissociating from D2, theses drugs (mainly clozapine and quetiapine) seemnotto inducedysphoria,unlike conventional antipsychotics like haloperidol;(3) these drugs (mainly clozapine) seem more effective in the treatment of negative symptoms than conventional antipsychotics; (4) because of a diversified activity on several serotoninergic and noradrenergic receptors,these drugs positively alter mood,which does not seem to be the case with conventional antipsychotics, except for flupenthixol; (5) these drugs have apositive impact on cognition,which is not the case with the firstgeneration antipsychotics; (6) unlike conventional antipsychotics, these drugs seem to have amoderate affinityfor 5-HT3, the receptor on which ondansetron, an anti-craving medication, acts." @default.
- W2029931114 created "2016-06-24" @default.
- W2029931114 creator A5032024974 @default.
- W2029931114 creator A5043353145 @default.
- W2029931114 creator A5045083719 @default.
- W2029931114 date "2003-05-01" @default.
- W2029931114 modified "2023-09-24" @default.
- W2029931114 title "Clozapine, quetiapine and olanzapine among addicted schizophrenic patients" @default.
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