FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029935428> ?p ?o ?g. }

• W2029935428 endingPage "e29912" @default.
• W2029935428 startingPage "e29912" @default.
• W2029935428 abstract "The guanine-nucleotide exchange factor Trio encodes two DH-PH domains that catalyze nucleotide exchange on Rac1, RhoG and RhoA. The N-terminal DH-PH domain is known to activate Rac1 and RhoG, whereas the C-terminal DH-PH domain can activate RhoA. The current study shows that the N-terminal DH-PH domain, upon expression in HeLa cells, activates Rac1 and RhoG independently from each other. In addition, we show that the flanking SH3 domain binds to the proline-rich region of the C-terminus of Rac1, but not of RhoG. However, this SH3 domain is not required for Rac1 or RhoG GDP-GTP exchange. Rescue experiments in Trio-shRNA-expressing cells showed that the N-terminal DH-PH domain of Trio, but not the C-terminal DH-PH domain, restored fibronectin-mediated cell spreading and migration defects that are observed in Trio-silenced cells. Kymograph analysis revealed that the N-terminal DH-PH domain, independent of its SH3 domain, controls the dynamics of lamellipodia. Using siRNA against Rac1 or RhoG, we found that Trio-D1-induced lamellipodia formation required Rac1 but not RhoG expression. Together, we conclude that the GEF Trio is responsible for lamellipodia formation through its N-terminal DH-PH domain in a Rac1-dependent manner during fibronectin-mediated spreading and migration." @default.
• W2029935428 created "2016-06-24" @default.
• W2029935428 creator A5007988336 @default.
• W2029935428 creator A5034913105 @default.
• W2029935428 creator A5066012252 @default.
• W2029935428 creator A5081335260 @default.
• W2029935428 creator A5087169555 @default.
• W2029935428 date "2012-01-06" @default.
• W2029935428 modified "2023-10-16" @default.
• W2029935428 title "The N-Terminal DH-PH Domain of Trio Induces Cell Spreading and Migration by Regulating Lamellipodia Dynamics in a Rac1-Dependent Fashion" @default.
• W2029935428 cites W1522344314 @default.
• W2029935428 cites W1611448597 @default.
• W2029935428 cites W1963238049 @default.
• W2029935428 cites W1971928903 @default.
• W2029935428 cites W1994687618 @default.
• W2029935428 cites W2007289852 @default.
• W2029935428 cites W2007660746 @default.
• W2029935428 cites W2009542532 @default.
• W2029935428 cites W2011815143 @default.
• W2029935428 cites W2013273457 @default.
• W2029935428 cites W2028295057 @default.
• W2029935428 cites W2028627377 @default.
• W2029935428 cites W2053431375 @default.
• W2029935428 cites W2055518825 @default.
• W2029935428 cites W2060818768 @default.
• W2029935428 cites W2067541328 @default.
• W2029935428 cites W2067861954 @default.
• W2029935428 cites W2083309890 @default.
• W2029935428 cites W2088623241 @default.
• W2029935428 cites W2093226717 @default.
• W2029935428 cites W2098414179 @default.
• W2029935428 cites W2103828505 @default.
• W2029935428 cites W2106249746 @default.
• W2029935428 cites W2109137906 @default.
• W2029935428 cites W2114902150 @default.
• W2029935428 cites W2116877714 @default.
• W2029935428 cites W2130172628 @default.
• W2029935428 cites W2132793070 @default.
• W2029935428 cites W2146473598 @default.
• W2029935428 cites W2146761810 @default.
• W2029935428 cites W2160600730 @default.
• W2029935428 doi "https://doi.org/10.1371/journal.pone.0029912" @default.
• W2029935428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253119" @default.
• W2029935428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22238672" @default.
• W2029935428 hasPublicationYear "2012" @default.
• W2029935428 type Work @default.
• W2029935428 sameAs 2029935428 @default.
• W2029935428 citedByCount "40" @default.
• W2029935428 countsByYear W20299354282012 @default.
• W2029935428 countsByYear W20299354282013 @default.
• W2029935428 countsByYear W20299354282014 @default.
• W2029935428 countsByYear W20299354282015 @default.
• W2029935428 countsByYear W20299354282016 @default.
• W2029935428 countsByYear W20299354282017 @default.
• W2029935428 countsByYear W20299354282018 @default.
• W2029935428 countsByYear W20299354282019 @default.
• W2029935428 countsByYear W20299354282020 @default.
• W2029935428 countsByYear W20299354282021 @default.
• W2029935428 countsByYear W20299354282022 @default.
• W2029935428 countsByYear W20299354282023 @default.
• W2029935428 crossrefType "journal-article" @default.
• W2029935428 hasAuthorship W2029935428A5007988336 @default.
• W2029935428 hasAuthorship W2029935428A5034913105 @default.
• W2029935428 hasAuthorship W2029935428A5066012252 @default.
• W2029935428 hasAuthorship W2029935428A5081335260 @default.
• W2029935428 hasAuthorship W2029935428A5087169555 @default.
• W2029935428 hasBestOaLocation W20299354281 @default.
• W2029935428 hasConcept C109185818 @default.
• W2029935428 hasConcept C126619667 @default.
• W2029935428 hasConcept C137738243 @default.
• W2029935428 hasConcept C1491633281 @default.
• W2029935428 hasConcept C153911025 @default.
• W2029935428 hasConcept C185592680 @default.
• W2029935428 hasConcept C207332259 @default.
• W2029935428 hasConcept C2777093181 @default.
• W2029935428 hasConcept C2779717556 @default.
• W2029935428 hasConcept C55493867 @default.
• W2029935428 hasConcept C62478195 @default.
• W2029935428 hasConcept C86803240 @default.
• W2029935428 hasConcept C95444343 @default.
• W2029935428 hasConceptScore W2029935428C109185818 @default.
• W2029935428 hasConceptScore W2029935428C126619667 @default.
• W2029935428 hasConceptScore W2029935428C137738243 @default.
• W2029935428 hasConceptScore W2029935428C1491633281 @default.
• W2029935428 hasConceptScore W2029935428C153911025 @default.
• W2029935428 hasConceptScore W2029935428C185592680 @default.
• W2029935428 hasConceptScore W2029935428C207332259 @default.
• W2029935428 hasConceptScore W2029935428C2777093181 @default.
• W2029935428 hasConceptScore W2029935428C2779717556 @default.
• W2029935428 hasConceptScore W2029935428C55493867 @default.
• W2029935428 hasConceptScore W2029935428C62478195 @default.
• W2029935428 hasConceptScore W2029935428C86803240 @default.
• W2029935428 hasConceptScore W2029935428C95444343 @default.
• W2029935428 hasIssue "1" @default.
• W2029935428 hasLocation W20299354281 @default.
• W2029935428 hasLocation W20299354282 @default.
• W2029935428 hasLocation W20299354283 @default.
• W2029935428 hasLocation W20299354284 @default.

• next