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• W2029941625 abstract "Toxic equivalency factors (TEFs), which relate the potency of individual polychlorinated dibenzo-p-dioxin (PCDD), dibenzofuran (PCDF), and biphenyl (PCB) congeners to 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD), are used to assess the risk to fish early life stage development posed by complex mixtures of these congeners in eggs. Newly fertilized rainbow trout (Oncorhynchus mykiss) eggs were injected with graded doses of 5 PCDD, 4 PCDF or 4 nonortho substituted PCB congeners, and sac fry mortality was used to determine TEFs. Potencies of non-ortho substituted PCBs in causing early life stage mortality were much lower than expected based on Ah receptor binding affinities in mammals and 4 mono-ortho and 5 di-ortho substituted PCB congeners did not cause rainbow trout early life stage mortality at doses of 24 300–130 000 ng/g egg. To determine if increased elimination of PCBs, relative to PCDDs and PCDFs, was responsible for the lower toxic potency of PCBs in fish compared to mammals, PCDD, PCDF and PCB congeners were injected into newly fertilized rainbow trout eggs and the percent dose remaining 35 days later at the sac fry stage of development was determined. The percent dose of various PCB congeners remaining in sac fry (62–88%) was similar to that of PCDD and PCDF congeners (78–91%), indicating that increased elimination is not responsible for the extremely low potency of the non-ortho substituted PCB congeners or for the failure of the mono- and di-ortho substituted PCB congeners to cause rainbow trout early life stage mortality." @default.
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• W2029941625 date "1995-04-01" @default.
• W2029941625 modified "2023-10-17" @default.
• W2029941625 title "Toxic equivalency factors of polychlorinated dibenzo-p-dioxin, dibenzofuran and biphenyl congeners based on early life stage mortality in rainbow trout (Oncorhynchus mykiss)" @default.
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• W2029941625 doi "https://doi.org/10.1016/0166-445x(94)00075-2" @default.
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