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- W2029946543 abstract "Simple, inexpensive and wide-scaled analysis of single DNA base changes (‘point mutations’ which include SNP's, somatic mutations and epigenetic changes) is one of the holy grail's of point-of-care diagnostics. Herein, we present eLCR: a simple methodology that fuses Ligase Chain Reaction (LCR) with electrochemical detection based on DNA-mediated charge transport. LCR generates long and short “knife” motifs representing the presence or absence of single DNA base changes, which are then detected electrochemically by either methylene blue intercalation or horseradish peroxidase labelling." @default.
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- W2029946543 date "2012-01-01" @default.
- W2029946543 modified "2023-10-18" @default.
- W2029946543 title "eLCR: electrochemical detection of single DNA base changes via Ligase Chain Reaction" @default.
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- W2029946543 doi "https://doi.org/10.1039/c2cc35841g" @default.
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