Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029958712> ?p ?o ?g. }
- W2029958712 endingPage "305" @default.
- W2029958712 startingPage "295" @default.
- W2029958712 abstract "The acyl-chain composition of the major mammalian phospholipid phosphatidylcholine (PC) is distinct in various tissues. Although it was classically suggested that PC diversity is acquired through acyl-chain remodeling, the mechanisms and biological relevance of acyl-chain diversity remain unclear. Here, we show that differences in the substrate selectivity of lysophospholipid acyltransferases regulate tissue PC acyl-chain composition through contribution of both the de novo and remodeling pathways, depending on the fatty acid species. Unexpectedly, while dipalmitoyl-PC (DPPC) is enriched through the remodeling pathway, several polyunsaturated PC molecules accumulate during the de novo pathway. We confirmed this concept for DPPC in pulmonary surfactant and showed that the biophysical properties of this lipid are important to prevent the early onset of acute lung injury. We propose a model of harmonized processes for phospholipid diversification to satisfy in vivo requirements, with an example of its biological relevance." @default.
- W2029958712 created "2016-06-24" @default.
- W2029958712 creator A5000508958 @default.
- W2029958712 creator A5001651899 @default.
- W2029958712 creator A5008934626 @default.
- W2029958712 creator A5011441043 @default.
- W2029958712 creator A5036596658 @default.
- W2029958712 creator A5048397528 @default.
- W2029958712 creator A5057121724 @default.
- W2029958712 creator A5061509682 @default.
- W2029958712 creator A5062413427 @default.
- W2029958712 creator A5067463702 @default.
- W2029958712 date "2014-08-01" @default.
- W2029958712 modified "2023-10-16" @default.
- W2029958712 title "Lysophospholipid Acyltransferases Mediate Phosphatidylcholine Diversification to Achieve the Physical Properties Required In Vivo" @default.
- W2029958712 cites W1566201062 @default.
- W2029958712 cites W1893515444 @default.
- W2029958712 cites W1965419967 @default.
- W2029958712 cites W1967968986 @default.
- W2029958712 cites W1973944606 @default.
- W2029958712 cites W1974083452 @default.
- W2029958712 cites W1974778705 @default.
- W2029958712 cites W1977911448 @default.
- W2029958712 cites W1979827108 @default.
- W2029958712 cites W1982268890 @default.
- W2029958712 cites W1990014836 @default.
- W2029958712 cites W1998323589 @default.
- W2029958712 cites W2001282262 @default.
- W2029958712 cites W2002755874 @default.
- W2029958712 cites W2012216316 @default.
- W2029958712 cites W2012835349 @default.
- W2029958712 cites W2012880347 @default.
- W2029958712 cites W2014169018 @default.
- W2029958712 cites W2014243370 @default.
- W2029958712 cites W2020552116 @default.
- W2029958712 cites W2033997896 @default.
- W2029958712 cites W2042815880 @default.
- W2029958712 cites W2043425632 @default.
- W2029958712 cites W2049271632 @default.
- W2029958712 cites W2054526538 @default.
- W2029958712 cites W2058906522 @default.
- W2029958712 cites W2061802019 @default.
- W2029958712 cites W2076822925 @default.
- W2029958712 cites W2077369999 @default.
- W2029958712 cites W2081934181 @default.
- W2029958712 cites W2095777272 @default.
- W2029958712 cites W2107589307 @default.
- W2029958712 cites W2114312858 @default.
- W2029958712 cites W2120276871 @default.
- W2029958712 cites W2125872855 @default.
- W2029958712 cites W2142973230 @default.
- W2029958712 cites W2148403724 @default.
- W2029958712 cites W2149214195 @default.
- W2029958712 cites W2150961941 @default.
- W2029958712 cites W2153974854 @default.
- W2029958712 cites W2158572777 @default.
- W2029958712 cites W2159763561 @default.
- W2029958712 cites W2167743972 @default.
- W2029958712 doi "https://doi.org/10.1016/j.cmet.2014.05.019" @default.
- W2029958712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24981836" @default.
- W2029958712 hasPublicationYear "2014" @default.
- W2029958712 type Work @default.
- W2029958712 sameAs 2029958712 @default.
- W2029958712 citedByCount "122" @default.
- W2029958712 countsByYear W20299587122014 @default.
- W2029958712 countsByYear W20299587122015 @default.
- W2029958712 countsByYear W20299587122016 @default.
- W2029958712 countsByYear W20299587122017 @default.
- W2029958712 countsByYear W20299587122018 @default.
- W2029958712 countsByYear W20299587122019 @default.
- W2029958712 countsByYear W20299587122020 @default.
- W2029958712 countsByYear W20299587122021 @default.
- W2029958712 countsByYear W20299587122022 @default.
- W2029958712 countsByYear W20299587122023 @default.
- W2029958712 crossrefType "journal-article" @default.
- W2029958712 hasAuthorship W2029958712A5000508958 @default.
- W2029958712 hasAuthorship W2029958712A5001651899 @default.
- W2029958712 hasAuthorship W2029958712A5008934626 @default.
- W2029958712 hasAuthorship W2029958712A5011441043 @default.
- W2029958712 hasAuthorship W2029958712A5036596658 @default.
- W2029958712 hasAuthorship W2029958712A5048397528 @default.
- W2029958712 hasAuthorship W2029958712A5057121724 @default.
- W2029958712 hasAuthorship W2029958712A5061509682 @default.
- W2029958712 hasAuthorship W2029958712A5062413427 @default.
- W2029958712 hasAuthorship W2029958712A5067463702 @default.
- W2029958712 hasBestOaLocation W20299587121 @default.
- W2029958712 hasConcept C150903083 @default.
- W2029958712 hasConcept C180899940 @default.
- W2029958712 hasConcept C181199279 @default.
- W2029958712 hasConcept C185592680 @default.
- W2029958712 hasConcept C207001950 @default.
- W2029958712 hasConcept C2776330855 @default.
- W2029958712 hasConcept C2778918659 @default.
- W2029958712 hasConcept C2781170229 @default.
- W2029958712 hasConcept C2910079589 @default.
- W2029958712 hasConcept C41625074 @default.
- W2029958712 hasConcept C553450214 @default.
- W2029958712 hasConcept C55493867 @default.