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- W2029965122 abstract "A method for the determination of d- and l-propranolol in human plasma is described. The method involves extraction of propranolol from plasma, and the formation of diastereomeric derivatives with the chiral reagent N-trifluoroacetyl-1-prolylchloride. Separation and quantitation of the diastereomeric propranolol derivatives are carried out by a reversed-phase high-performance liquid-chromatographic system with fluorimetric detection. The reproducibility in the determination of d- and l-propranolol in human plasma was 4.5% (relative standard deviation) at drug levels of 10 ng/ml. In two subjects who received a single 40-mg tablet of racemic propranolol the plasma levels of the d-isomer were lower than of the l-propranolol. The half-lives of d- and l-propranolol were similar." @default.
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- W2029965122 date "1980-11-01" @default.
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- W2029965122 title "Simultaneous determination of d- and l-propranolol in human plasma by high-performance liquid chromatography" @default.
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- W2029965122 doi "https://doi.org/10.1016/s0378-4347(00)81012-9" @default.
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