FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029966770> ?p ?o ?g. }

• W2029966770 abstract "Abstract Background Heliconius butterflies are an excellent system for studies of adaptive convergent and divergent phenotypic traits. Wing colour patterns are used as signals to both predators and potential mates and are inherited in a Mendelian manner. The underlying genetic mechanisms of pattern formation have been studied for many years and shed light on broad issues, such as the repeatability of evolution. In Heliconius melpomene , the yellow hindwing bar is controlled by the HmYb locus. MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that have key roles in many biological processes, including development. miRNAs could act as regulators of genes involved in wing development, patterning and pigmentation. For this reason we characterised miRNAs in developing butterfly wings and examined differences in their expression between colour pattern races. Results We sequenced small RNA libraries from two colour pattern races and detected 142 Heliconius miRNAs with homology to others found in miRBase. Several highly abundant miRNAs were differentially represented in the libraries between colour pattern races. These candidates were tested further using Northern blots, showing that differences in expression were primarily due to developmental stage rather than colour pattern. Assembly of sequenced reads to the HmYb region identified hme-miR-193 and hme-miR-2788; located 2380 bp apart in an intergenic region. These two miRNAs are expressed in wings and show an upregulation between 24 and 72 hours post-pupation, indicating a potential role in butterfly wing development. A search for miRNAs in all available H. melpomene BAC sequences (~ 2.5 Mb) did not reveal any other miRNAs and no novel miRNAs were predicted. Conclusions Here we describe the first butterfly miRNAs and characterise their expression in developing wings. Some show differences in expression across developing pupal stages and may have important functions in butterfly wing development. Two miRNAs were located in the HmYb region and were expressed in developing pupal wings. Future work will examine the expression of these miRNAs in different colour pattern races and identify miRNA targets among wing patterning genes." @default.
• W2029966770 created "2016-06-24" @default.
• W2029966770 creator A5004432790 @default.
• W2029966770 creator A5004770698 @default.
• W2029966770 creator A5008262717 @default.
• W2029966770 creator A5036215936 @default.
• W2029966770 creator A5042194478 @default.
• W2029966770 creator A5047919368 @default.
• W2029966770 creator A5078089858 @default.
• W2029966770 creator A5086622827 @default.
• W2029966770 date "2011-01-26" @default.
• W2029966770 modified "2023-10-18" @default.
• W2029966770 title "Characterisation and expression of microRNAs in developing wings of the neotropical butterfly Heliconius melpomene" @default.
• W2029966770 cites W144423133 @default.
• W2029966770 cites W1490776936 @default.
• W2029966770 cites W1593322865 @default.
• W2029966770 cites W1958284284 @default.
• W2029966770 cites W1967408983 @default.
• W2029966770 cites W1967517087 @default.
• W2029966770 cites W1973320270 @default.
• W2029966770 cites W1973726689 @default.
• W2029966770 cites W1978944350 @default.
• W2029966770 cites W1993386570 @default.
• W2029966770 cites W2001150039 @default.
• W2029966770 cites W2005476363 @default.
• W2029966770 cites W2008273315 @default.
• W2029966770 cites W2009972611 @default.
• W2029966770 cites W2020541351 @default.
• W2029966770 cites W2039606711 @default.
• W2029966770 cites W2040648064 @default.
• W2029966770 cites W2042693809 @default.
• W2029966770 cites W2046214303 @default.
• W2029966770 cites W2046733425 @default.
• W2029966770 cites W2047862598 @default.
• W2029966770 cites W2058538156 @default.
• W2029966770 cites W2065416213 @default.
• W2029966770 cites W2065997193 @default.
• W2029966770 cites W2089329577 @default.
• W2029966770 cites W2097324875 @default.
• W2029966770 cites W2101952636 @default.
• W2029966770 cites W2102326716 @default.
• W2029966770 cites W2112243861 @default.
• W2029966770 cites W2115324145 @default.
• W2029966770 cites W2121410013 @default.
• W2029966770 cites W2133407503 @default.
• W2029966770 cites W2135106597 @default.
• W2029966770 cites W2136839011 @default.
• W2029966770 cites W2140123373 @default.
• W2029966770 cites W2140413201 @default.
• W2029966770 cites W2141311279 @default.
• W2029966770 cites W2141623813 @default.
• W2029966770 cites W2143463816 @default.
• W2029966770 cites W2146580685 @default.
• W2029966770 cites W2147154770 @default.
• W2029966770 cites W2147908409 @default.
• W2029966770 cites W2160970041 @default.
• W2029966770 cites W2164432010 @default.
• W2029966770 cites W2165849608 @default.
• W2029966770 cites W2168546553 @default.
• W2029966770 cites W2169416219 @default.
• W2029966770 cites W2169919568 @default.
• W2029966770 cites W2172793464 @default.
• W2029966770 doi "https://doi.org/10.1186/1471-2164-12-62" @default.
• W2029966770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3039609" @default.
• W2029966770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21266089" @default.
• W2029966770 hasPublicationYear "2011" @default.
• W2029966770 type Work @default.
• W2029966770 sameAs 2029966770 @default.
• W2029966770 citedByCount "41" @default.
• W2029966770 countsByYear W20299667702012 @default.
• W2029966770 countsByYear W20299667702013 @default.
• W2029966770 countsByYear W20299667702014 @default.
• W2029966770 countsByYear W20299667702015 @default.
• W2029966770 countsByYear W20299667702016 @default.
• W2029966770 countsByYear W20299667702017 @default.
• W2029966770 countsByYear W20299667702018 @default.
• W2029966770 countsByYear W20299667702019 @default.
• W2029966770 countsByYear W20299667702020 @default.
• W2029966770 countsByYear W20299667702021 @default.
• W2029966770 countsByYear W20299667702022 @default.
• W2029966770 countsByYear W20299667702023 @default.
• W2029966770 crossrefType "journal-article" @default.
• W2029966770 hasAuthorship W2029966770A5004432790 @default.
• W2029966770 hasAuthorship W2029966770A5004770698 @default.
• W2029966770 hasAuthorship W2029966770A5008262717 @default.
• W2029966770 hasAuthorship W2029966770A5036215936 @default.
• W2029966770 hasAuthorship W2029966770A5042194478 @default.
• W2029966770 hasAuthorship W2029966770A5047919368 @default.
• W2029966770 hasAuthorship W2029966770A5078089858 @default.
• W2029966770 hasAuthorship W2029966770A5086622827 @default.
• W2029966770 hasBestOaLocation W20299667701 @default.
• W2029966770 hasConcept C104317684 @default.
• W2029966770 hasConcept C145059251 @default.
• W2029966770 hasConcept C168601633 @default.
• W2029966770 hasConcept C18903297 @default.
• W2029966770 hasConcept C2776713692 @default.
• W2029966770 hasConcept C2778605236 @default.
• W2029966770 hasConcept C49305753 @default.
• W2029966770 hasConcept C54355233 @default.
• W2029966770 hasConcept C78458016 @default.

• next