FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029972227> ?p ?o ?g. }

• W2029972227 abstract "Abstract We previously reported that protein kinase A activity is an important determinant of thyroid cell survival. Given the important role of cAMP response element binding protein (CREB) in mediating the transcriptional effects of protein kinase A, we explored whether interference with CREB family members impaired thyroid cell survival. Expression of A-CREB, a dominant-negative CREB mutant that inhibits CREB DNA binding activity, induced apoptosis in rat thyroid cells. A-CREB inhibited CRE-regulated gene expression but failed to alter the expression of bcl-2 family members or of well-characterized inhibitors of apoptosis. To elucidate the mechanism through which impaired CREB function triggered apoptosis, its effects on cell proliferation were examined. Expression of A-CREB inhibited cell number increases, in part due to delayed cell cycle transit. Protracted S-phase progression in A-CREB-expressing cells was sufficient to activate a checkpoint response characterized by Chk-1, histone H2A.X, and p53 phosphorylation. To determine whether cell cycle progression was required for apoptosis, the effects of p27 overexpression were investigated. Overexpression of p27 prevented cell cycle progression, checkpoint activation, and apoptosis in A-CREB-expressing cells. These data reveal a novel mechanism through which interference with CREB abrogates cell survival, through checkpoint activation secondary to cell cycle delay. This study may explain how interference with CREB induces apoptosis in cells where alterations in the expression of pro- and anti-survival genes are not detected." @default.
• W2029972227 created "2016-06-24" @default.
• W2029972227 creator A5033709422 @default.
• W2029972227 creator A5072427916 @default.
• W2029972227 date "2006-05-01" @default.
• W2029972227 modified "2023-10-16" @default.
• W2029972227 title "Interference with 3′,5′-Cyclic Adenosine Monophosphate Response Element Binding Protein Stimulates Apoptosis through Aberrant Cell Cycle Progression and Checkpoint Activation" @default.
• W2029972227 cites W10025872 @default.
• W2029972227 cites W1492232967 @default.
• W2029972227 cites W1514042105 @default.
• W2029972227 cites W1640418706 @default.
• W2029972227 cites W1874291746 @default.
• W2029972227 cites W1965239527 @default.
• W2029972227 cites W1968777078 @default.
• W2029972227 cites W1969562461 @default.
• W2029972227 cites W1973132231 @default.
• W2029972227 cites W1975290731 @default.
• W2029972227 cites W1976195850 @default.
• W2029972227 cites W1976441097 @default.
• W2029972227 cites W1984374041 @default.
• W2029972227 cites W1988004907 @default.
• W2029972227 cites W1988256844 @default.
• W2029972227 cites W1990898737 @default.
• W2029972227 cites W1992872303 @default.
• W2029972227 cites W1999095014 @default.
• W2029972227 cites W2000206408 @default.
• W2029972227 cites W2003608181 @default.
• W2029972227 cites W2005779191 @default.
• W2029972227 cites W2006254842 @default.
• W2029972227 cites W2007990425 @default.
• W2029972227 cites W2011089421 @default.
• W2029972227 cites W2013336412 @default.
• W2029972227 cites W2018036981 @default.
• W2029972227 cites W2018136707 @default.
• W2029972227 cites W2022568067 @default.
• W2029972227 cites W2027099095 @default.
• W2029972227 cites W2030364029 @default.
• W2029972227 cites W2031062185 @default.
• W2029972227 cites W2034485619 @default.
• W2029972227 cites W2039841141 @default.
• W2029972227 cites W2049439285 @default.
• W2029972227 cites W2051881152 @default.
• W2029972227 cites W2052613680 @default.
• W2029972227 cites W2057022989 @default.
• W2029972227 cites W2059971436 @default.
• W2029972227 cites W2061523903 @default.
• W2029972227 cites W2068252839 @default.
• W2029972227 cites W2077755090 @default.
• W2029972227 cites W2082559623 @default.
• W2029972227 cites W2084350197 @default.
• W2029972227 cites W2095022409 @default.
• W2029972227 cites W2095435531 @default.
• W2029972227 cites W2115717647 @default.
• W2029972227 cites W2120165202 @default.
• W2029972227 cites W2125495844 @default.
• W2029972227 cites W2130513979 @default.
• W2029972227 cites W2133578739 @default.
• W2029972227 cites W2147266699 @default.
• W2029972227 cites W2150958450 @default.
• W2029972227 cites W2165991181 @default.
• W2029972227 cites W2168969237 @default.
• W2029972227 cites W2317721149 @default.
• W2029972227 doi "https://doi.org/10.1210/me.2005-0386" @default.
• W2029972227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16410315" @default.
• W2029972227 hasPublicationYear "2006" @default.
• W2029972227 type Work @default.
• W2029972227 sameAs 2029972227 @default.
• W2029972227 citedByCount "7" @default.
• W2029972227 countsByYear W20299722272014 @default.
• W2029972227 countsByYear W20299722272016 @default.
• W2029972227 crossrefType "journal-article" @default.
• W2029972227 hasAuthorship W2029972227A5033709422 @default.
• W2029972227 hasAuthorship W2029972227A5072427916 @default.
• W2029972227 hasBestOaLocation W20299722271 @default.
• W2029972227 hasConcept C104317684 @default.
• W2029972227 hasConcept C105696609 @default.
• W2029972227 hasConcept C1629964 @default.
• W2029972227 hasConcept C190283241 @default.
• W2029972227 hasConcept C29537977 @default.
• W2029972227 hasConcept C50001416 @default.
• W2029972227 hasConcept C502942594 @default.
• W2029972227 hasConcept C55493867 @default.
• W2029972227 hasConcept C62112901 @default.
• W2029972227 hasConcept C86339819 @default.
• W2029972227 hasConcept C86803240 @default.
• W2029972227 hasConcept C95444343 @default.
• W2029972227 hasConceptScore W2029972227C104317684 @default.
• W2029972227 hasConceptScore W2029972227C105696609 @default.
• W2029972227 hasConceptScore W2029972227C1629964 @default.
• W2029972227 hasConceptScore W2029972227C190283241 @default.
• W2029972227 hasConceptScore W2029972227C29537977 @default.
• W2029972227 hasConceptScore W2029972227C50001416 @default.
• W2029972227 hasConceptScore W2029972227C502942594 @default.
• W2029972227 hasConceptScore W2029972227C55493867 @default.
• W2029972227 hasConceptScore W2029972227C62112901 @default.
• W2029972227 hasConceptScore W2029972227C86339819 @default.
• W2029972227 hasConceptScore W2029972227C86803240 @default.
• W2029972227 hasConceptScore W2029972227C95444343 @default.
• W2029972227 hasLocation W20299722271 @default.
• W2029972227 hasLocation W20299722272 @default.

• next