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• W2029972466 abstract "The purpose of this study was to investigate the cellular composition of peritoneal fluid during post-surgical re-epithelialization and to determine the metabolism of arachidonic acid by these cells. Rabbits underwent a midline laparotomy followed by abrasion of the broad ligament. The presence of adhesions was graded and the peritoneal exudative cells collected up to 14 days thereafter. Ascitic fluid and cells were separated by centrifugation and the cellular percipitate incubated with [14C]arachidonic acid. The aliquot was separated by silica Gel G thin-layer chromatography and the specific radioactivity of each strip determined. To evaluate the reformation of adhesions 14 days after the first abrasion, rabbits underwent reabrasion of the same area and the pattern of arachidonic acid metabolism by the ascites cells was similarly evaluated. Six hours after the abrasion, PMNs comprised 87.5% of the peritoneal exudative cells (total 0.03 × 107 cells/rabbit). On Day 3, the total cell number increased to 2.92 × 107, 97.6% of which were large mononuclear cells. No significant change in the type or distribution of adhesions was evident from 6 hr through Day 2. After Day 7, the total number of adhesions was minimal; however, those that were present were primarily severe. The second-look evaluation of adhesion formation was not found to be consistent prior to the 7th postoperative day, since many filmy bands present prior to that time were not present later. The in vitro formation of 5-HETE by these cells increased from 6 hr through Day 11. Production of di-HETE increased beginning Day 3 and maintained high steady state levels thereafter. 15-HETE levels increased relatively abruptly from 6 hr to Day 1 and continued to increase thereafter. 6-keto-PGF1a levels rapidly increased over the initial 24 hr and remained at almost the same concentration. Although TxB2 and PGE2 were at relative low concentrations 6 hr after peritoneal injury, production of these metabolites dramatically increased through the later phase of healing. Reabrasion was followed by a lesser number of leukocytes in the peritoneal fluid compared to the initial abrasion. The percentage of macrophages in the peritoneal fluid 24 hr after the reabrasion procedure was higher than after the first abrasion. The incidence of severe adhesions after reabrasion was also higher than after the first abrasion. The formation of TxB2 and 15-HETE by macrophages recovered from the peritoneal fluid 1 day after reabrasion was greater than after the initial abrasion. Since the marked increase in the number of macrophages paralleled the increase in arachidonic acid metabolites, recruitment of an active cellular element into the site of tissue healing (i.e., the activated postsurgical macrophage) accompanied postsurgical repair. These findings lend in vitro support to the clinical observation of repetitious adhesion reformation and suggest that the balance of biochemical mediators involved in initial adhesion formation may not be identical to those involved in adhesion reformation." @default.
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• W2029972466 date "1986-09-01" @default.
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• W2029972466 title "A kinetic analysis of peritoneal fluid cytology and arachidonic acid metabolism after abrasion and reabrasion of rabbit peritoneum" @default.
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• W2029972466 doi "https://doi.org/10.1016/0022-4804(86)90031-4" @default.
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