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- W2029972800 abstract "A facile synthetic pathway for preparing block copolymers with pH-responsive l-glutamic acid segments for membrane disruption is reported. Aqueous reversible addition–fragmentation chain transfer (aRAFT) polymerization was first used to prepare biocompatible, nonimmunogenic poly[N-(2-hydroxypropyl)methacrylamide]. This macro chain transfer agent (CTA) was then converted into a macroinitiator via simultaneous aminolysis and thiol–ene Michael addition using the primary amine substituted N-(3-aminopropyl)methacrylamide. This macroinitiator was subsequently utilized in the ring-opening polymerization of the N-carboxyanhydride monomer of γ-benzyl-l-glutamate. After deprotection, the pH-dependent coil-to-helix transformations of the resulting HPMA-b-(l-Glu) copolymers were monitored via circular dichroism spectroscopy. HPMA segments confer water solubility and biocompatibility while the l-glutamic acid repeats provide reversible coil-to-helix transitions at endosomal pH values (∼5–6). The endolytic properties of these novel [HPMA-b-(l-Glu)] copolymers and their potential as modular components in drug carrier constructs was demonstrated utilizing red blood cell hemolysis and fluorescein release from POPC vesicles." @default.
- W2029972800 created "2016-06-24" @default.
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- W2029972800 date "2013-10-02" @default.
- W2029972800 modified "2023-10-12" @default.
- W2029972800 title "Endolytic, pH-Responsive HPMA-<i>b</i>-(<scp>l</scp>-Glu) Copolymers Synthesized via Sequential Aqueous RAFT and Ring-Opening Polymerizations" @default.
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- W2029972800 doi "https://doi.org/10.1021/bm401205y" @default.
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