Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029974727> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2029974727 endingPage "363" @default.
- W2029974727 startingPage "353" @default.
- W2029974727 abstract "The pharmacological profile of Org 10172, a mixture of sulphated glycosaminoglycorunans derived from hog intestinal mucosa, has been assessed in experimental thrombosis and bleeding models in rats and compared with heparin USP. Org 10172 inhibited thrombus formation in arterio-venous shunts dose dependently, the dose required for 50% inhibition (ID50) of thrombus formation was 40 anti-Xa units/kg i.v. The ID50 for heparin USP was 70 anti-Xa units/kg i.v. Org 10172 hardly increased bleeding in doses upto 1600 anti-Xa units/kg i.v., whereas heparin USP dose dependently increased bleeding from 90 anti-Xa units/kg i.v. onwards. The benefit (anti-thrombotic)/risk (bleeding) ratio of Org 10172 was therefore considerably better than that of heparin USP. The improved profile of Org 10172 towards bleeding might be caused by differences in the interaction with blood platelets in comparison with heparin USP. Org 10172 had less effect on the platelet content in thrombi than heparin USP. Org 10172 did not inhibit collagen induced release of serotonin in contrast to heparin USP. Org 10172 inhibited factor Xa induced aggregation of rabbit platelets but only at anti-Xa levels which were fifteen times higher than for heparin USP. In contrast to heparin USP Org 10172 had only a very weak effect on the activated partial thromboplastin time (APTT) ex vivo." @default.
- W2029974727 created "2016-06-24" @default.
- W2029974727 creator A5005936284 @default.
- W2029974727 creator A5023084789 @default.
- W2029974727 creator A5026572418 @default.
- W2029974727 creator A5038895248 @default.
- W2029974727 date "1982-08-01" @default.
- W2029974727 modified "2023-09-27" @default.
- W2029974727 title "A novel anti-thrombotic heparinoid (ORG 10172) devoid of bleeding inducing capacity: A survey of its pharmacological properties in experimental animal models" @default.
- W2029974727 cites W1553230769 @default.
- W2029974727 cites W1976414763 @default.
- W2029974727 cites W1985485198 @default.
- W2029974727 cites W2012214760 @default.
- W2029974727 cites W2024317151 @default.
- W2029974727 cites W2039396916 @default.
- W2029974727 cites W2091772699 @default.
- W2029974727 cites W2092886792 @default.
- W2029974727 cites W2112799238 @default.
- W2029974727 cites W2132469330 @default.
- W2029974727 cites W2203822312 @default.
- W2029974727 cites W2233495119 @default.
- W2029974727 cites W2328440105 @default.
- W2029974727 cites W2333330110 @default.
- W2029974727 cites W2338122996 @default.
- W2029974727 cites W4249054346 @default.
- W2029974727 doi "https://doi.org/10.1016/0049-3848(82)90082-2" @default.
- W2029974727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6182627" @default.
- W2029974727 hasPublicationYear "1982" @default.
- W2029974727 type Work @default.
- W2029974727 sameAs 2029974727 @default.
- W2029974727 citedByCount "86" @default.
- W2029974727 countsByYear W20299747272013 @default.
- W2029974727 countsByYear W20299747272017 @default.
- W2029974727 countsByYear W20299747272019 @default.
- W2029974727 countsByYear W20299747272021 @default.
- W2029974727 crossrefType "journal-article" @default.
- W2029974727 hasAuthorship W2029974727A5005936284 @default.
- W2029974727 hasAuthorship W2029974727A5023084789 @default.
- W2029974727 hasAuthorship W2029974727A5026572418 @default.
- W2029974727 hasAuthorship W2029974727A5038895248 @default.
- W2029974727 hasConcept C126322002 @default.
- W2029974727 hasConcept C185592680 @default.
- W2029974727 hasConcept C2776884760 @default.
- W2029974727 hasConcept C2777557582 @default.
- W2029974727 hasConcept C2778261982 @default.
- W2029974727 hasConcept C2779863229 @default.
- W2029974727 hasConcept C2781362458 @default.
- W2029974727 hasConcept C55493867 @default.
- W2029974727 hasConcept C71924100 @default.
- W2029974727 hasConcept C89560881 @default.
- W2029974727 hasConcept C98274493 @default.
- W2029974727 hasConceptScore W2029974727C126322002 @default.
- W2029974727 hasConceptScore W2029974727C185592680 @default.
- W2029974727 hasConceptScore W2029974727C2776884760 @default.
- W2029974727 hasConceptScore W2029974727C2777557582 @default.
- W2029974727 hasConceptScore W2029974727C2778261982 @default.
- W2029974727 hasConceptScore W2029974727C2779863229 @default.
- W2029974727 hasConceptScore W2029974727C2781362458 @default.
- W2029974727 hasConceptScore W2029974727C55493867 @default.
- W2029974727 hasConceptScore W2029974727C71924100 @default.
- W2029974727 hasConceptScore W2029974727C89560881 @default.
- W2029974727 hasConceptScore W2029974727C98274493 @default.
- W2029974727 hasIssue "3" @default.
- W2029974727 hasLocation W20299747271 @default.
- W2029974727 hasLocation W20299747272 @default.
- W2029974727 hasOpenAccess W2029974727 @default.
- W2029974727 hasPrimaryLocation W20299747271 @default.
- W2029974727 hasRelatedWork W1600823549 @default.
- W2029974727 hasRelatedWork W1995760661 @default.
- W2029974727 hasRelatedWork W2029974727 @default.
- W2029974727 hasRelatedWork W2048929842 @default.
- W2029974727 hasRelatedWork W2073399472 @default.
- W2029974727 hasRelatedWork W2088992810 @default.
- W2029974727 hasRelatedWork W2108777072 @default.
- W2029974727 hasRelatedWork W2123421678 @default.
- W2029974727 hasRelatedWork W2413564373 @default.
- W2029974727 hasRelatedWork W2416233937 @default.
- W2029974727 hasVolume "27" @default.
- W2029974727 isParatext "false" @default.
- W2029974727 isRetracted "false" @default.
- W2029974727 magId "2029974727" @default.
- W2029974727 workType "article" @default.