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• W2029978834 startingPage "334" @default.
• W2029978834 abstract "The regulatory mechanisms mediating basal and inducible platelet-derived growth factor (PDGF)-A expression have been the focus of intense recent investigation, but repression of PDGF-A expression is largely unexplored. Here we isolated a nuclear factor that interacts with the proximal region of the PDGF-A promoter using bulk binding assays and chromatography techniques. Peptide mass fingerprint and supershift analysis revealed this DNA-binding protein to be NF1/X. NF1/X repressed PDGF-A promoter-dependent transcription and endogenous mRNA expression, which was reversible by oligonucleotide decoys bearing an NF1/X-binding site. Mutation in the DNA-binding domain of NF1/X abolished its repression of PDGF-A promoter. NF1/X antagonized the activity of a known activator of the PDGF-A chain, Sp1, by inhibiting its occupancy of the proximal PDGF-A promoter. NF1/X physically and specifically interacts with Sp1 via its subtype-specific domain and blocks Sp1 induction of the promoter. NF1/X residues 311-416 mediated NF1/X suppression of basal PDGF-A transcription, whereas residues 243-416 were required for NF1/X repression of Sp1-inducible promoter activity. These findings demonstrate that repression of PDGF-A gene transcription is governed by interplay between NF1/X and Sp1." @default.
• W2029978834 created "2016-06-24" @default.
• W2029978834 creator A5012564439 @default.
• W2029978834 creator A5016487477 @default.
• W2029978834 creator A5065860849 @default.
• W2029978834 date "2002-02-01" @default.
• W2029978834 modified "2023-10-18" @default.
• W2029978834 title "NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter" @default.
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• W2029978834 doi "https://doi.org/10.1093/emboj/21.3.334" @default.
• W2029978834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125828" @default.
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