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- W2029984976 abstract "A comparison was made between the pulsatile pattern of growth hormone secretion In 14 growth hormone deficient adults (serum growth hormone less than 7 mU/l following insulin-stimulated hypoglycaemia) and 14 age and sex matched controls. The 24-h secretory profile was generated by 2-hourly sampling from 0800 to 2200 h, and 30-min sampling from 2200 to 0600 h. Plasma GH in each sample was measured using a double antibody radloimmunoassay. The profiles were analysed using a computer program (Pulsar). Sleep-electroencephalography was recorded In all subjects. The total amount of GH secreted In a 24-h period (area under the curve over baseline) was significantly less In the growth hormone deficient group (P > 0·002). The pulse frequency, amplitude, height and percentage GH secreted in peaks were also significantly less in the growth hormone deficient group (P > 0± 002 respectively). We conclude that adults deficient In GH, as defined by conventional pharmacological stimuli, are in addition physiologically deficient of pulsatile GH secretion." @default.
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- W2029984976 date "1991-05-01" @default.
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- W2029984976 title "Physiological growth hormone secretion in adult growth hormone deficiency: comparison with normal controls" @default.
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- W2029984976 doi "https://doi.org/10.1111/j.1365-2265.1991.tb00307.x" @default.
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