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- W2029991736 abstract "Propionibacterium acnes (P. acnes) bacteria play a key role in the pathogenesis of acne vulgaris. Although our previous studies have demonstrated that vaccines targeting a surface sialidase or bacterial particles exhibit a preventive effect against P. acnes, the lack of therapeutic activities and incapability of neutralizing secretory virulence factors motivate us to generate novel immunotherapeutics. In this study, we develop an immunotherapeutic antibody to secretory Christie–Atkins–Munch-Peterson (CAMP) factor of P. acnes. Via agroinfiltration, P. acnes CAMP factor was encapsulated into the leaves of radishes. ICR mice intranasally immunized with whole leaves expressing CAMP factor successfully produced neutralizing antibodies that efficiently attenuated P. acnes-induced ear swelling and production of macrophage-inflammatory protein-2. Passive neutralization of CAMP factor enhanced immunity to eradicate P. acnes at the infection site without influencing bacterial growth elsewhere. We propose that CAMP factor is a novel therapeutic target for the treatment of various P. acnes-associated diseases and highlight the concept of neutralizing P. acnes virulence without disturbing the bacterial commensalism in human micorbiome." @default.
- W2029991736 created "2016-06-24" @default.
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- W2029991736 date "2011-04-01" @default.
- W2029991736 modified "2023-10-14" @default.
- W2029991736 title "Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris" @default.
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- W2029991736 doi "https://doi.org/10.1016/j.vaccine.2011.02.036" @default.
- W2029991736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3388602" @default.
- W2029991736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21354482" @default.
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