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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029992005> ?p ?o ?g. }

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• W2029992005 abstract "Abstract We describe here that the requirement of accessory cells for the polyclonal activation of high‐density (resting) murine T lymphocytes can be bypassed by soluble mediators present in culture supernatants of concanavalin A (Con A)‐activated murine spleen cells. Induction of responsiveness is confined to Lyt‐2 + T cells; GK 1.5 + T helper cells require signals provided by accessory cells. Using this system the lymphokine signal requirements for the polyclonal activation of Lyt‐2 + cytotoxic T lymphocyte (CTL) precursors could be defined. We show that Con A fails to trigger in Lyt‐2 + responder T cells the expression of interleukin 2 (IL 2) receptors and assume that this explains why recombinant (rec) DNA‐derived IL2 fails to induce proliferative responses. Complementation of rec IL2 with an IL2 receptor‐inducing factor (RIF) induces proliferative responses. RIF alone triggers IL2 receptor expression in 10–12% of Lyt‐2 + T cells exposed to Con A. This lymphokine appears to be distinct from colony‐stimulating factor 1, IFN‐γ and IL1. Resting Lyt‐2 + T cells cultured in limiting numbers in the presence of Con A, RIF plus rec IL2 do proliferate, yet exhibit no cytolytic activity. Differentiation into CTL can be brought about by addition of cytotoxic T cell differentiation factor (CTDF). We conclude that the polyclonal activation pathway of CTL from resting CTL precursors can be subdivided into three stages: preactivation, clonal growth and CTL differentiation. Each of these stages appears to be controlled by a distinct lymphokine, RIF, IL2 and CTDF, respectively." @default.
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• W2029992005 title "Signal requirements for thein vitro differentiation of cytotoxic T lymphocytes (CTL): distinct soluble mediators promote preactivation of CTL-precursors, clonal growth and differentiation into cytotoxic effector cells" @default.
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• W2029992005 doi "https://doi.org/10.1002/eji.1830150511" @default.
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