Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029994024> ?p ?o ?g. }
- W2029994024 endingPage "1371" @default.
- W2029994024 startingPage "1371" @default.
- W2029994024 abstract "To investigate the host defense against Staphylococcus in the rabbit anterior chamber.The bactericidal activity of rabbit aqueous humor was investigated in vitro. Rabbit anterior chambers were injected with viable Staphylococcus aureus or Staphylococcus epidermidis (1,000 or 500,000 colony-forming units [CFU]), killed bacteria, culture supernatants of either organism, or purified S. aureus alpha-toxin. CFU as well as phospholipase (PLA(2)) and myeloperoxidase (MPO) activities of aqueous humor were determined up to 25 hours postinfection (PI).The number of viable S. aureus or S. epidermidis was significantly reduced when incubated with aqueous humor for 30 minutes (P </= 0.0001). Rabbits challenged with either S. aureus or S. epidermidis demonstrated a significant reduction in CFU in aqueous humor by 1 hour PI (P </= 0.0044). Eyes infected with either S. aureus or S. epidermidis demonstrated a significant increase in MPO activity beginning at 1 hour PI (P </= 0.0455), but only S. aureus caused an increase in PLA(2) activity at 20 and 25 hours PI (P </= 0.0002). No significant increases in PLA(2) activity were observed after injection of killed bacteria into the aqueous humor at any time point; however, injection of S. aureus supernatant or alpha-toxin into the anterior chamber significantly increased PLA(2) activity (P </= 0.0210). Injection of alpha-toxin also resulted in significant increases in MPO activity beginning at 10 hours after injection (P </= 0.001).This study demonstrates that aqueous humor has a potent host defense capability and that S. aureus, but not S. epidermidis, triggers a PLA(2) response in the rabbit anterior chamber that appears to be due to alpha-toxin." @default.
- W2029994024 created "2016-06-24" @default.
- W2029994024 creator A5036656088 @default.
- W2029994024 creator A5043536765 @default.
- W2029994024 creator A5045664077 @default.
- W2029994024 creator A5063198129 @default.
- W2029994024 creator A5080979214 @default.
- W2029994024 creator A5081779551 @default.
- W2029994024 creator A5089985618 @default.
- W2029994024 date "2005-04-01" @default.
- W2029994024 modified "2023-09-28" @default.
- W2029994024 title "Pathogenesis ofStaphylococcusin the Rabbit Anterior Chamber" @default.
- W2029994024 cites W106235802 @default.
- W2029994024 cites W139932544 @default.
- W2029994024 cites W1537546513 @default.
- W2029994024 cites W1585336866 @default.
- W2029994024 cites W1603382924 @default.
- W2029994024 cites W1607470432 @default.
- W2029994024 cites W165354613 @default.
- W2029994024 cites W176626716 @default.
- W2029994024 cites W186541823 @default.
- W2029994024 cites W189844474 @default.
- W2029994024 cites W1967365364 @default.
- W2029994024 cites W1970706237 @default.
- W2029994024 cites W1977151226 @default.
- W2029994024 cites W2007965377 @default.
- W2029994024 cites W2010899052 @default.
- W2029994024 cites W2012390916 @default.
- W2029994024 cites W2015897844 @default.
- W2029994024 cites W2016484956 @default.
- W2029994024 cites W2019917639 @default.
- W2029994024 cites W2020418000 @default.
- W2029994024 cites W2025875311 @default.
- W2029994024 cites W2026593223 @default.
- W2029994024 cites W2032068809 @default.
- W2029994024 cites W2052929273 @default.
- W2029994024 cites W2056087367 @default.
- W2029994024 cites W2064755891 @default.
- W2029994024 cites W2066505820 @default.
- W2029994024 cites W2067959871 @default.
- W2029994024 cites W2071766701 @default.
- W2029994024 cites W2090223653 @default.
- W2029994024 cites W2094601440 @default.
- W2029994024 cites W2094923761 @default.
- W2029994024 cites W2096304810 @default.
- W2029994024 cites W2108599200 @default.
- W2029994024 cites W2115017482 @default.
- W2029994024 cites W2116229252 @default.
- W2029994024 cites W2118078151 @default.
- W2029994024 cites W2123795230 @default.
- W2029994024 cites W2131727773 @default.
- W2029994024 cites W2132911499 @default.
- W2029994024 cites W2137474950 @default.
- W2029994024 cites W2144472726 @default.
- W2029994024 cites W2154883084 @default.
- W2029994024 cites W34158357 @default.
- W2029994024 cites W50336777 @default.
- W2029994024 cites W91650790 @default.
- W2029994024 doi "https://doi.org/10.1167/iovs.04-0888" @default.
- W2029994024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15790904" @default.
- W2029994024 hasPublicationYear "2005" @default.
- W2029994024 type Work @default.
- W2029994024 sameAs 2029994024 @default.
- W2029994024 citedByCount "9" @default.
- W2029994024 countsByYear W20299940242014 @default.
- W2029994024 countsByYear W20299940242018 @default.
- W2029994024 crossrefType "journal-article" @default.
- W2029994024 hasAuthorship W2029994024A5036656088 @default.
- W2029994024 hasAuthorship W2029994024A5043536765 @default.
- W2029994024 hasAuthorship W2029994024A5045664077 @default.
- W2029994024 hasAuthorship W2029994024A5063198129 @default.
- W2029994024 hasAuthorship W2029994024A5080979214 @default.
- W2029994024 hasAuthorship W2029994024A5081779551 @default.
- W2029994024 hasAuthorship W2029994024A5089985618 @default.
- W2029994024 hasConcept C185592680 @default.
- W2029994024 hasConcept C202751555 @default.
- W2029994024 hasConcept C203014093 @default.
- W2029994024 hasConcept C203565725 @default.
- W2029994024 hasConcept C2776914184 @default.
- W2029994024 hasConcept C2777367657 @default.
- W2029994024 hasConcept C2777949923 @default.
- W2029994024 hasConcept C2779489039 @default.
- W2029994024 hasConcept C2780942790 @default.
- W2029994024 hasConcept C523546767 @default.
- W2029994024 hasConcept C54355233 @default.
- W2029994024 hasConcept C55493867 @default.
- W2029994024 hasConcept C86803240 @default.
- W2029994024 hasConcept C89423630 @default.
- W2029994024 hasConceptScore W2029994024C185592680 @default.
- W2029994024 hasConceptScore W2029994024C202751555 @default.
- W2029994024 hasConceptScore W2029994024C203014093 @default.
- W2029994024 hasConceptScore W2029994024C203565725 @default.
- W2029994024 hasConceptScore W2029994024C2776914184 @default.
- W2029994024 hasConceptScore W2029994024C2777367657 @default.
- W2029994024 hasConceptScore W2029994024C2777949923 @default.
- W2029994024 hasConceptScore W2029994024C2779489039 @default.
- W2029994024 hasConceptScore W2029994024C2780942790 @default.
- W2029994024 hasConceptScore W2029994024C523546767 @default.