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• W2029996498 abstract "Data sources Sources were MEDLINE and the Cochrane Oral Health Group Trials Register. Reference lists from relevant articles, and selected journals dated up to April 2001, were also searched by hand. Study selection Randomised controlled trials (RCT) were selected if they were of at least 6 months' duration and they compared the grafting of biomaterials or biological agents — alone or in combination — plus OFD (including open flap curettage, access flap surgery, modified Widman flap) to OFD alone or in combination with a placebo. Any type of grafting biomaterials or biological agents, apart from guided tissue regeneration, alone or in combination with other biomaterials/biological agents were considered. Data extraction and synthesis Information regarding the quality and characteristics of studies were extracted independently by two reviewers. Short-term, long-term and a range of patient-centred outcomes were assessed. The main short-term outcomes were the changes in clinical attachment levels (CAL) and probing pocket depth (PPD). Long-term measures included disease recurrence — measured as the proportion of defects presenting loss of CAL and/or bone, as assessed clinically or radiographically from 12 months after intervention — and the change of CAL from 6–12 months up to the last observation interval. A weighted treatment effect was calculated and the results were expressed as weighted mean differences for continuous outcome variables using both fixed and random models. The analysis for the continuous outcome variables was conducted using Stata (version 6; Stata Corporation, College Station, Texas, USA) to combine parallel-group and intra-individual (split-mouth) studies. Results The difference in CAL change between test and control groups varied from −1.45 mm to 1.40 mm with respect to different biomaterials or biological agents. Meta-analysis showed that CAL significantly improved after treatment with coralline calcium carbonate (weighted mean difference, 0.90 mm; 95% confidence interval (CI), 0.53–1.27), bioactive glass (weighted mean difference, 1.04 mm; 95% CI, 0.31–1.76), hydroxyapatite (weighted mean difference, 1.40 mm; 95% CI, 0.64–2.16) and enamel matrix proteins (weighted mean difference, 1.33 mm, 95% CI, 0.78–1.88). Heterogeneity in the results between studies was highly statistically significant, however, for most biomaterials or biologicals; this could not be fully explained. Conclusions Overall, the use of specific biomaterials or biological agents was more effective than OFD in improving attachment levels in intraosseous defects. Difference in CAL gain varied greatly with respect to different biomaterials/biological agents. Because of the significant heterogeneity in results between studies in most treatment groups, general conclusions about the clinical benefit of graft biomaterials/biologicals need to be interpreted with caution." @default.
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• W2029996498 date "2003-09-01" @default.
• W2029996498 modified "2023-10-12" @default.
• W2029996498 title "Is grafting biomaterials or biological agents more effective than open-flap debridement in treating deep intraosseous defects?" @default.
• W2029996498 cites W1517898854 @default.
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• W2029996498 doi "https://doi.org/10.1038/sj.ebd.6400195" @default.
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