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• W2029996884 abstract "<b><i>Background:</i></b> To evaluate the treatment outcome of gemcitabine and cisplatin combination therapy as second-line treatment for advanced biliary tract cancer. <b><i>Patients and Methods:</i></b> Patients with advanced biliary tract cancer who were refractory to gemcitabine-based first-line chemotherapy were treated with gemcitabine and cisplatin combination therapy. Gemcitabine (1,000 mg/m²) and cisplatin (25 mg/m²) were administered intravenously on days 1 and 8, repeated every 3 weeks. <b><i>Results:</i></b> Sixty patients were included. The tumor response and disease control rates were 1.7 and 58.3%, respectively. The median overall survival and time to progression were 6.7 months (95% CI 4.9-8.1) and 3.5 months (95% CI 2.5-5.0), respectively. Grade 3/4 toxicities included leucopenia (20%), neutropenia (25%), anemia (23%), thrombocytopenia (17%), nausea (2%), anorexia (2%), and liver dysfunction (2%). <b><i>Conclusions:</i></b> Gemcitabine and cisplatin combination therapy showed moderate efficacy and safety as second-line treatment for advanced biliary tract cancer that is refractory to gemcitabine-based first-line chemotherapy." @default.
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• W2029996884 date "2013-01-01" @default.
• W2029996884 modified "2023-10-04" @default.
• W2029996884 title "A Retrospective Study of Gemcitabine and Cisplatin Combination Therapy as Second-Line Treatment for Advanced Biliary Tract Cancer" @default.
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• W2029996884 doi "https://doi.org/10.1159/000354209" @default.
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